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UBE2C [cytosol]
Stable Identifier
R-BTA-174244
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
UBE2C, Q32PA5
Locations in the PathwayBrowser
Expand all
Cell Cycle (Bos taurus)
Cell Cycle Checkpoints (Bos taurus)
Mitotic Spindle Checkpoint (Bos taurus)
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Bos taurus)
Inactivation of APC/C via direct inhibition of the APC/C complex (Bos taurus)
Binding of the MCC complex to the APC/C complex (Bos taurus)
MCC:APC/C complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
Cell Cycle, Mitotic (Bos taurus)
M Phase (Bos taurus)
Mitotic Metaphase and Anaphase (Bos taurus)
Mitotic Anaphase (Bos taurus)
Separation of Sister Chromatids (Bos taurus)
Association of Securin with Cdc20:APC/C complex (Bos taurus)
CDC20:p-APC/C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
CDC20:p-APC/C:PTTG1 [cytosol] (Bos taurus)
CDC20:p-APC/C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
Degradation of multiubiquitinated Securin (Bos taurus)
CDC20:p-APC/C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Bos taurus)
CDC20:p-APC/C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Bos taurus)
CDC20:p-APC/C:PTTG1 [cytosol] (Bos taurus)
CDC20:p-APC/C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Bos taurus)
CDC20:p-APC/C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
Regulation of mitotic cell cycle (Bos taurus)
APC/C-mediated degradation of cell cycle proteins (Bos taurus)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Bos taurus)
APC/C:Cdh1 polyubiquitinates SKP2 (Bos taurus)
UBE2C [cytosol] (Bos taurus)
Association of cell cycle proteins with the APC/C:Cdh1 complex (Bos taurus)
(APC/C:Cdh1)-targeted cell cycle proteins [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Bos taurus)
(APC/C:Cdh1)-targeted cell cycle proteins [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
phospho-APC/C:Cdh1 complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
phospho-APC/C:Cdh1 complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
Degradation of multiubiquitinated cell cycle proteins (Bos taurus)
multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Bos taurus)
cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Bos taurus)
(APC/C:Cdh1)-targeted cell cycle proteins [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
phospho-APC/C:Cdh1 complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
phospho-APC/C:Cdh1 complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Bos taurus)
cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Bos taurus)
(APC/C:Cdh1)-targeted cell cycle proteins [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
phospho-APC/C:Cdh1 complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Bos taurus)
cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Bos taurus)
(APC/C:Cdh1)-targeted cell cycle proteins [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
phospho-APC/C:Cdh1 complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Bos taurus)
APC/C:Cdc20 mediated degradation of mitotic proteins (Bos taurus)
APC/C:Cdc20 mediated degradation of Cyclin B (Bos taurus)
Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Bos taurus)
CDC20:p-APC/C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Bos taurus)
CDC20:p-APC/C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
Degradation of multiubiquitinated Cyclin B (Bos taurus)
CDC20:p-APC/C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Bos taurus)
Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Bos taurus)
CDC20:p-APC/C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Bos taurus)
Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Bos taurus)
CDC20:p-APC/C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Bos taurus)
Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Bos taurus)
CDC20:p-APC/C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
APC/C:Cdc20 mediated degradation of Securin (Bos taurus)
Association of Securin with Cdc20:APC/C complex (Bos taurus)
CDC20:p-APC/C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
CDC20:p-APC/C:PTTG1 [cytosol] (Bos taurus)
CDC20:p-APC/C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
Degradation of multiubiquitinated Securin (Bos taurus)
CDC20:p-APC/C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Bos taurus)
CDC20:p-APC/C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Bos taurus)
CDC20:p-APC/C:PTTG1 [cytosol] (Bos taurus)
CDC20:p-APC/C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Bos taurus)
CDC20:p-APC/C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Bos taurus)
APC-Cdc20 mediated degradation of Nek2A (Bos taurus)
Association of Nek2A with MCC:APC/C (Bos taurus)
MCC:APC/C complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
Nek2A:MCC:APC/C complex [cytosol] (Bos taurus)
MCC:APC/C complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
Degradation of multiubiquitinated Nek2A (Bos taurus)
MCC:APC/C complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
Multiubiquitinated Nek2A [cytosol] (Bos taurus)
Nek2A:MCC:APC/C complex [cytosol] (Bos taurus)
MCC:APC/C complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
Multiubiquitination of Nek2A (Bos taurus)
Multiubiquitinated Nek2A [cytosol] (Bos taurus)
Nek2A:MCC:APC/C complex [cytosol] (Bos taurus)
MCC:APC/C complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
Nek2A:MCC:APC/C complex [cytosol] (Bos taurus)
MCC:APC/C complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Bos taurus)
Association of Cyclin A with the APC/C (Bos taurus)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Bos taurus)
MCC:APC/C complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
MCC:APC/C complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
Degradation multiubiquitinated Cyclin A (Bos taurus)
MCC:APC/C complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Bos taurus)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Bos taurus)
MCC:APC/C complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Bos taurus)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Bos taurus)
MCC:APC/C complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
MCC:APC/C complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Bos taurus)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Bos taurus)
MCC:APC/C complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Bos taurus)
CDC20:p-APC/C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
MCC:APC/C complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Bos taurus)
Association of Cdh1 with the APC/C (Bos taurus)
phospho-APC/C:Cdh1 complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
Dissociation of Cdc20 from APC/C complex (Bos taurus)
CDC20:p-APC/C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
Regulation of APC/C activators between G1/S and early anaphase (Bos taurus)
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Bos taurus)
Inactivation of APC/C via direct inhibition of the APC/C complex (Bos taurus)
Binding of the MCC complex to the APC/C complex (Bos taurus)
MCC:APC/C complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
S Phase (Bos taurus)
Synthesis of DNA (Bos taurus)
Switching of origins to a post-replicative state (Bos taurus)
CDK-mediated phosphorylation and removal of Cdc6 (Bos taurus)
Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Bos taurus)
phospho-APC/C:Cdh1 complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
DNA Replication (Bos taurus)
Synthesis of DNA (Bos taurus)
Switching of origins to a post-replicative state (Bos taurus)
CDK-mediated phosphorylation and removal of Cdc6 (Bos taurus)
Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Bos taurus)
phospho-APC/C:Cdh1 complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Class I MHC mediated antigen processing & presentation (Bos taurus)
Antigen processing: Ubiquitination & Proteasome degradation (Bos taurus)
Interaction of E3 with substrate and E2-Ub complex (Bos taurus)
Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
Ubiquitin:E2 conjugating enzymes [cytosol] (Bos taurus)
E2 Ubiquitin-conjugating enzyme [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
Ubiquitin:E2 conjugating enzymes [cytosol] (Bos taurus)
E2 Ubiquitin-conjugating enzyme [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
Polyubiquitination of substrate (Bos taurus)
E2 Ubiquitin-conjugating enzyme [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
Ubiquitin:E2 conjugating enzymes [cytosol] (Bos taurus)
E2 Ubiquitin-conjugating enzyme [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
Transfer of Ub from E2 to substrate and release of E2 (Bos taurus)
Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
Ubiquitin:E2 conjugating enzymes [cytosol] (Bos taurus)
E2 Ubiquitin-conjugating enzyme [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
E2 Ubiquitin-conjugating enzyme [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
Transfer of ubiquitin from E1 to E2 (Bos taurus)
E2 Ubiquitin-conjugating enzyme [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
Ubiquitin:E2 conjugating enzymes [cytosol] (Bos taurus)
E2 Ubiquitin-conjugating enzyme [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Protein ubiquitination (Bos taurus)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Bos taurus)
UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Bos taurus)
E2 ubiquitin conjugating enzyme (UBA1 substrate) [cytosol] (Bos taurus)
UBE2C [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:Q32PA5
Gene Names
UBE2C
Reference Genes
BioGPS Gene:506962 UBE2C
ENSEMBL:ENSBTAG00000016746
KEGG Gene (Bos taurus):506962 UBE2C
Monarch:506962 UBE2C
NCBI Gene:506962 UBE2C
Reference Transcript
RefSeq:NM_001037449.2 UBE2C
Other Identifiers
506962
GO:0000151
GO:0000166
GO:0000209
GO:0000278
GO:0003824
GO:0004842
GO:0005524
GO:0005634
GO:0005680
GO:0005829
GO:0005886
GO:0006511
GO:0007049
GO:0007059
GO:0010458
GO:0010994
GO:0016567
GO:0016740
GO:0019538
GO:0030071
GO:0030163
GO:0031145
GO:0031536
GO:0036211
GO:0043226
GO:0044389
GO:0045842
GO:0051301
GO:0061631
GO:0065003
GO:0070936
GO:0070979
GO:0140014
GO:0140096
Participates
as a member of
E2 ubiquitin conjugating enzyme (UBA1 substrate) [cytosol] (Bos taurus)
(APC/C:Cdh1)-targeted cell cycle proteins [cytosol] (Bos taurus)
as a candidate of
E2 Ubiquitin-conjugating enzyme [cytosol] (Bos taurus)
as a component of
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
Other forms of this molecule
UBE2C [cytosol]
UBE2C [nucleoplasm]
UBE2C [nucleoplasm]
Inferred From
UBE2C [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001032526.1
OpenTargets
ENSG00000175063
Ensembl
ENSBTAT00000079595
,
ENSBTAP00000061332
,
ENSBTAG00000016746
VGNC
36578
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