Reactome | 6MP [extracellular region]

6MP [extracellular region]

Stable Identifier

R-ALL-9751015

Type

ChemicalDrug

Compartment

extracellular region

Synonyms

6-mercaptopurine, Mercaptopurine

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External Reference Information

External Reference

mercaptopurine [Guide to Pharmacology:7226]

Participates

as an input of

SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Caenorhabditis elegans)
SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Drosophila melanogaster)
SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Gallus gallus)
SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Xenopus tropicalis)
SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Sus scrofa)
SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Bos taurus)
SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Canis familiaris)
SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Rattus norvegicus)
SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Mus musculus)
SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Homo sapiens)
SLC29A1,2 transport 6MP from extracellular region to cytosol (Plasmodium falciparum)
SLC29A1,2 transport 6MP from extracellular region to cytosol (Dictyostelium discoideum)
SLC29A1,2 transport 6MP from extracellular region to cytosol (Caenorhabditis elegans)
SLC29A1,2 transport 6MP from extracellular region to cytosol (Drosophila melanogaster)
SLC29A1,2 transport 6MP from extracellular region to cytosol (Xenopus tropicalis)
SLC29A1,2 transport 6MP from extracellular region to cytosol (Danio rerio)
SLC29A1,2 transport 6MP from extracellular region to cytosol (Sus scrofa)
SLC29A1,2 transport 6MP from extracellular region to cytosol (Bos taurus)
SLC29A1,2 transport 6MP from extracellular region to cytosol (Canis familiaris)
SLC29A1,2 transport 6MP from extracellular region to cytosol (Rattus norvegicus)
SLC29A1,2 transport 6MP from extracellular region to cytosol (Mus musculus)
SLC29A1,2 transport 6MP from extracellular region to cytosol (Homo sapiens)

as an output of

GSH cleaves AZA to 6MP (Homo sapiens)

Other forms of this molecule

6MP [cytosol]

Disease

Name	Identifier	Synonyms
ulcerative colitis	DOID:8577	Left-sided ulcerative colitis
Crohn's disease	DOID:8778	Crohn disease, Pediatric Crohn's disease, Granulomatous Colitis, Crohn's disease of large bowel, Crohn's disease of colon

Cross References

PharmacoDB

PDBC00164

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