Reactome | SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol

SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol

Stable Identifier

R-HSA-9751037

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane, extracellular region

ReviewStatus

5/5

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SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol

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Candidates for the transport of thiopurines like 6-mercaptopurine (6MP) into the cell include the sodium-dependent transporters SLC28A2 (concentrative Na(+)-nucleoside cotransporter 2, CNT2) and SLC28A3 (concentrative Na(+)-nucleoside cotransporter 3, CNT3). Down-regulation of these influx transporters may play a major role in 6MP resistance of cells (Fotoohi et al. 2006, Peng et al. 2008, Karim et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
17996297	Up-regulation of MRP4 and down-regulation of influx transporters in human leukemic cells with acquired resistance to 6-mercaptopurine Fu, L, Damaraju, VL, Chen, ZS, Shi, Z, Cass, CE, Wu, HC, Peng, XX, Zhou, Y, Tiwari, A, Kruh, GD, Huang, XC	Leuk Res	2008
16530731	Involvement of the concentrative nucleoside transporter 3 and equilibrative nucleoside transporter 2 in the resistance of T-lymphoblastic cell lines to thiopurines Peterson, C, Fotoohi, AK, Albertioni, F, Lindqvist, M	Biochem Biophys Res Commun	2006
21723252	The pattern of gene expression and gene dose profiles of 6-Mercaptopurine- and 6-Thioguanine-resistant human leukemia cells Moshfegh, A, Hashemi, J, Larsson, C, Karim, H, Albertioni, F, Fotoohi, AK	Biochem Biophys Res Commun	2011