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6MP [cytosol]
Stable Identifier
R-ALL-9748998
Type
ChemicalDrug
Compartment
cytosol
Synonyms
6-mercaptopurine, Mercaptopurine
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Sus scrofa
Xenopus tropicalis
Expand all
Drug ADME (Bos taurus)
Azathioprine ADME (Bos taurus)
GST dimers cleave AZA to 6MP (Bos taurus)
6MP [cytosol]
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Bos taurus)
6MP [cytosol]
SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Bos taurus)
6MP [cytosol]
SLC29A1,2 transport 6MP from extracellular region to cytosol (Bos taurus)
6MP [cytosol]
TPMT transfers methyl group to 6MP, forming 6MeMP (Bos taurus)
6MP [cytosol]
XDH oxidises 6MP to 6TU (Bos taurus)
6MP [cytosol]
Drug ADME (Caenorhabditis elegans)
Azathioprine ADME (Caenorhabditis elegans)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Caenorhabditis elegans)
6MP [cytosol]
SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Caenorhabditis elegans)
6MP [cytosol]
SLC29A1,2 transport 6MP from extracellular region to cytosol (Caenorhabditis elegans)
6MP [cytosol]
XDH oxidises 6MP to 6TU (Caenorhabditis elegans)
6MP [cytosol]
Drug ADME (Canis familiaris)
Azathioprine ADME (Canis familiaris)
GST dimers cleave AZA to 6MP (Canis familiaris)
6MP [cytosol]
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Canis familiaris)
6MP [cytosol]
SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Canis familiaris)
6MP [cytosol]
SLC29A1,2 transport 6MP from extracellular region to cytosol (Canis familiaris)
6MP [cytosol]
TPMT transfers methyl group to 6MP, forming 6MeMP (Canis familiaris)
6MP [cytosol]
XDH oxidises 6MP to 6TU (Canis familiaris)
6MP [cytosol]
Drug ADME (Danio rerio)
Azathioprine ADME (Danio rerio)
GST dimers cleave AZA to 6MP (Danio rerio)
6MP [cytosol]
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Danio rerio)
6MP [cytosol]
SLC29A1,2 transport 6MP from extracellular region to cytosol (Danio rerio)
6MP [cytosol]
TPMT transfers methyl group to 6MP, forming 6MeMP (Danio rerio)
6MP [cytosol]
Drug ADME (Dictyostelium discoideum)
Azathioprine ADME (Dictyostelium discoideum)
GST dimers cleave AZA to 6MP (Dictyostelium discoideum)
6MP [cytosol]
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Dictyostelium discoideum)
6MP [cytosol]
SLC29A1,2 transport 6MP from extracellular region to cytosol (Dictyostelium discoideum)
6MP [cytosol]
XDH oxidises 6MP to 6TU (Dictyostelium discoideum)
6MP [cytosol]
Drug ADME (Drosophila melanogaster)
Azathioprine ADME (Drosophila melanogaster)
SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Drosophila melanogaster)
6MP [cytosol]
SLC29A1,2 transport 6MP from extracellular region to cytosol (Drosophila melanogaster)
6MP [cytosol]
XDH oxidises 6MP to 6TU (Drosophila melanogaster)
6MP [cytosol]
Drug ADME (Gallus gallus)
Azathioprine ADME (Gallus gallus)
GST dimers cleave AZA to 6MP (Gallus gallus)
6MP [cytosol]
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Gallus gallus)
6MP [cytosol]
SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Gallus gallus)
6MP [cytosol]
TPMT transfers methyl group to 6MP, forming 6MeMP (Gallus gallus)
6MP [cytosol]
XDH oxidises 6MP to 6TU (Gallus gallus)
6MP [cytosol]
Drug ADME (Homo sapiens)
Azathioprine ADME (Homo sapiens)
GST dimers cleave AZA to 6MP (Homo sapiens)
6MP [cytosol]
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Homo sapiens)
6MP [cytosol]
SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Homo sapiens)
6MP [cytosol]
SLC29A1,2 transport 6MP from extracellular region to cytosol (Homo sapiens)
6MP [cytosol]
TPMT transfers methyl group to 6MP, forming 6MeMP (Homo sapiens)
6MP [cytosol]
XDH oxidises 6MP to 6TU (Homo sapiens)
6MP [cytosol]
Drug ADME (Mus musculus)
Azathioprine ADME (Mus musculus)
GST dimers cleave AZA to 6MP (Mus musculus)
6MP [cytosol]
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Mus musculus)
6MP [cytosol]
SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Mus musculus)
6MP [cytosol]
SLC29A1,2 transport 6MP from extracellular region to cytosol (Mus musculus)
6MP [cytosol]
TPMT transfers methyl group to 6MP, forming 6MeMP (Mus musculus)
6MP [cytosol]
XDH oxidises 6MP to 6TU (Mus musculus)
6MP [cytosol]
Drug ADME (Plasmodium falciparum)
Azathioprine ADME (Plasmodium falciparum)
GST dimers cleave AZA to 6MP (Plasmodium falciparum)
6MP [cytosol]
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Plasmodium falciparum)
6MP [cytosol]
SLC29A1,2 transport 6MP from extracellular region to cytosol (Plasmodium falciparum)
6MP [cytosol]
Drug ADME (Rattus norvegicus)
Azathioprine ADME (Rattus norvegicus)
GST dimers cleave AZA to 6MP (Rattus norvegicus)
6MP [cytosol]
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Rattus norvegicus)
6MP [cytosol]
SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Rattus norvegicus)
6MP [cytosol]
SLC29A1,2 transport 6MP from extracellular region to cytosol (Rattus norvegicus)
6MP [cytosol]
TPMT transfers methyl group to 6MP, forming 6MeMP (Rattus norvegicus)
6MP [cytosol]
XDH oxidises 6MP to 6TU (Rattus norvegicus)
6MP [cytosol]
Drug ADME (Sus scrofa)
Azathioprine ADME (Sus scrofa)
GST dimers cleave AZA to 6MP (Sus scrofa)
6MP [cytosol]
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Sus scrofa)
6MP [cytosol]
SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Sus scrofa)
6MP [cytosol]
SLC29A1,2 transport 6MP from extracellular region to cytosol (Sus scrofa)
6MP [cytosol]
TPMT transfers methyl group to 6MP, forming 6MeMP (Sus scrofa)
6MP [cytosol]
XDH oxidises 6MP to 6TU (Sus scrofa)
6MP [cytosol]
Drug ADME (Xenopus tropicalis)
Azathioprine ADME (Xenopus tropicalis)
GST dimers cleave AZA to 6MP (Xenopus tropicalis)
6MP [cytosol]
SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Xenopus tropicalis)
6MP [cytosol]
SLC29A1,2 transport 6MP from extracellular region to cytosol (Xenopus tropicalis)
6MP [cytosol]
TPMT transfers methyl group to 6MP, forming 6MeMP (Xenopus tropicalis)
6MP [cytosol]
XDH oxidises 6MP to 6TU (Xenopus tropicalis)
6MP [cytosol]
External Reference Information
External Reference
mercaptopurine [Guide to Pharmacology:7226]
Participates
as an input of
XDH oxidises 6MP to 6TU (Dictyostelium discoideum)
XDH oxidises 6MP to 6TU (Caenorhabditis elegans)
XDH oxidises 6MP to 6TU (Drosophila melanogaster)
XDH oxidises 6MP to 6TU (Gallus gallus)
XDH oxidises 6MP to 6TU (Xenopus tropicalis)
XDH oxidises 6MP to 6TU (Sus scrofa)
XDH oxidises 6MP to 6TU (Bos taurus)
XDH oxidises 6MP to 6TU (Canis familiaris)
XDH oxidises 6MP to 6TU (Rattus norvegicus)
XDH oxidises 6MP to 6TU (Mus musculus)
XDH oxidises 6MP to 6TU (Homo sapiens)
TPMT transfers methyl group to 6MP, forming 6MeMP (Gallus gallus)
TPMT transfers methyl group to 6MP, forming 6MeMP (Xenopus tropicalis)
TPMT transfers methyl group to 6MP, forming 6MeMP (Danio rerio)
TPMT transfers methyl group to 6MP, forming 6MeMP (Sus scrofa)
TPMT transfers methyl group to 6MP, forming 6MeMP (Bos taurus)
TPMT transfers methyl group to 6MP, forming 6MeMP (Canis familiaris)
TPMT transfers methyl group to 6MP, forming 6MeMP (Rattus norvegicus)
TPMT transfers methyl group to 6MP, forming 6MeMP (Mus musculus)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Homo sapiens)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Mus musculus)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Rattus norvegicus)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Canis familiaris)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Bos taurus)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Sus scrofa)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Danio rerio)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Gallus gallus)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Caenorhabditis elegans)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Dictyostelium discoideum)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Plasmodium falciparum)
TPMT transfers methyl group to 6MP, forming 6MeMP (Homo sapiens)
as an output of
SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Caenorhabditis elegans)
SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Drosophila melanogaster)
GST dimers cleave AZA to 6MP (Homo sapiens)
GST dimers cleave AZA to 6MP (Mus musculus)
GST dimers cleave AZA to 6MP (Rattus norvegicus)
GST dimers cleave AZA to 6MP (Canis familiaris)
GST dimers cleave AZA to 6MP (Bos taurus)
GST dimers cleave AZA to 6MP (Sus scrofa)
GST dimers cleave AZA to 6MP (Danio rerio)
GST dimers cleave AZA to 6MP (Xenopus tropicalis)
GST dimers cleave AZA to 6MP (Gallus gallus)
GST dimers cleave AZA to 6MP (Dictyostelium discoideum)
GST dimers cleave AZA to 6MP (Plasmodium falciparum)
SLC29A1,2 transport 6MP from extracellular region to cytosol (Homo sapiens)
SLC29A1,2 transport 6MP from extracellular region to cytosol (Mus musculus)
SLC29A1,2 transport 6MP from extracellular region to cytosol (Rattus norvegicus)
SLC29A1,2 transport 6MP from extracellular region to cytosol (Canis familiaris)
SLC29A1,2 transport 6MP from extracellular region to cytosol (Bos taurus)
SLC29A1,2 transport 6MP from extracellular region to cytosol (Sus scrofa)
SLC29A1,2 transport 6MP from extracellular region to cytosol (Danio rerio)
SLC29A1,2 transport 6MP from extracellular region to cytosol (Xenopus tropicalis)
SLC29A1,2 transport 6MP from extracellular region to cytosol (Drosophila melanogaster)
SLC29A1,2 transport 6MP from extracellular region to cytosol (Caenorhabditis elegans)
SLC29A1,2 transport 6MP from extracellular region to cytosol (Dictyostelium discoideum)
SLC29A1,2 transport 6MP from extracellular region to cytosol (Plasmodium falciparum)
SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Homo sapiens)
SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Mus musculus)
SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Rattus norvegicus)
SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Canis familiaris)
SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Bos taurus)
SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Sus scrofa)
SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Xenopus tropicalis)
SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Gallus gallus)
Other forms of this molecule
6MP [extracellular region]
Disease
Name
Identifier
Synonyms
Crohn's disease
DOID:8778
Crohn disease, Pediatric Crohn's disease, Granulomatous Colitis, Crohn's disease of large bowel, Crohn's disease of colon
ulcerative colitis
DOID:8577
Left-sided ulcerative colitis
Cross References
ChEBI
50667
PharmacoDB
PDBC00164
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