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Go!
APAP [cytosol]
Stable Identifier
R-ALL-9677362
Type
ChemicalDrug
Compartment
cytosol
Synonyms
paracetamol, acetaminophen, Panadol®, Tylenol®
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Rattus norvegicus
Sus scrofa
Xenopus tropicalis
Expand all
Drug ADME (Bos taurus)
Paracetamol ADME (Bos taurus)
CYP2E1 monooxygenates APAP to NAPQI (Bos taurus)
APAP [cytosol]
SULT dimers sulfate APAP to APAP-SO3 (Bos taurus)
APAP [cytosol]
UGTs glucuronate APAP to APAP-GlcA (Bos taurus)
APAP [cytosol]
Metabolism (Bos taurus)
Biological oxidations (Bos taurus)
Phase II - Conjugation of compounds (Bos taurus)
Cytosolic sulfonation of small molecules (Bos taurus)
SULT1A1 dimer sulfonates PARA to PARA-SO4 (Bos taurus)
APAP [cytosol]
Metabolism of lipids (Bos taurus)
Fatty acid metabolism (Bos taurus)
Arachidonate metabolism (Bos taurus)
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Bos taurus)
PTGS1 dimer binds PTGS1 Inhibitors (Bos taurus)
PTGS1 Inhibitors [cytosol]
APAP [cytosol]
PTGS1 dimer:PTGS1 Inhibitors [endoplasmic reticulum membrane] (Bos taurus)
PTGS1 Inhibitors [cytosol]
APAP [cytosol]
PTGS1,2 dimers bind PTGS Inhibitors (Bos taurus)
PTGS inhibitors [cytosol]
APAP [cytosol]
PTGS1 dimer:PTGS Inhibitors [endoplasmic reticulum membrane] (Bos taurus)
PTGS inhibitors [cytosol]
APAP [cytosol]
PTGS2 dimer:PTGS inhibitors [endoplasmic reticulum membrane] (Bos taurus)
PTGS inhibitors [cytosol]
APAP [cytosol]
PTGS2 dimer binds PTGS inhibitors (Bos taurus)
PTGS inhibitors [cytosol]
APAP [cytosol]
PTGS2 dimer:PTGS inhibitors [endoplasmic reticulum membrane] (Bos taurus)
PTGS inhibitors [cytosol]
APAP [cytosol]
Drug ADME (Caenorhabditis elegans)
Paracetamol ADME (Caenorhabditis elegans)
CYP2E1 monooxygenates APAP to NAPQI (Caenorhabditis elegans)
APAP [cytosol]
SULT dimers sulfate APAP to APAP-SO3 (Caenorhabditis elegans)
APAP [cytosol]
UGTs glucuronate APAP to APAP-GlcA (Caenorhabditis elegans)
APAP [cytosol]
Drug ADME (Canis familiaris)
Paracetamol ADME (Canis familiaris)
CYP2E1 monooxygenates APAP to NAPQI (Canis familiaris)
APAP [cytosol]
SULT dimers sulfate APAP to APAP-SO3 (Canis familiaris)
APAP [cytosol]
UGTs glucuronate APAP to APAP-GlcA (Canis familiaris)
APAP [cytosol]
Metabolism (Canis familiaris)
Biological oxidations (Canis familiaris)
Phase II - Conjugation of compounds (Canis familiaris)
Cytosolic sulfonation of small molecules (Canis familiaris)
SULT1A1 dimer sulfonates PARA to PARA-SO4 (Canis familiaris)
APAP [cytosol]
Metabolism of lipids (Canis familiaris)
Fatty acid metabolism (Canis familiaris)
Arachidonate metabolism (Canis familiaris)
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Canis familiaris)
PTGS1 dimer binds PTGS1 Inhibitors (Canis familiaris)
PTGS1 Inhibitors [cytosol]
APAP [cytosol]
PTGS1 dimer:PTGS1 Inhibitors [endoplasmic reticulum membrane] (Canis familiaris)
PTGS1 Inhibitors [cytosol]
APAP [cytosol]
PTGS1,2 dimers bind PTGS Inhibitors (Canis familiaris)
PTGS inhibitors [cytosol]
APAP [cytosol]
PTGS1 dimer:PTGS Inhibitors [endoplasmic reticulum membrane] (Canis familiaris)
PTGS inhibitors [cytosol]
APAP [cytosol]
PTGS2 dimer:PTGS inhibitors [endoplasmic reticulum membrane] (Canis familiaris)
PTGS inhibitors [cytosol]
APAP [cytosol]
PTGS2 dimer binds PTGS inhibitors (Canis familiaris)
PTGS inhibitors [cytosol]
APAP [cytosol]
PTGS2 dimer:PTGS inhibitors [endoplasmic reticulum membrane] (Canis familiaris)
PTGS inhibitors [cytosol]
APAP [cytosol]
Drug ADME (Danio rerio)
Paracetamol ADME (Danio rerio)
CYP2E1 monooxygenates APAP to NAPQI (Danio rerio)
APAP [cytosol]
SULT dimers sulfate APAP to APAP-SO3 (Danio rerio)
APAP [cytosol]
UGTs glucuronate APAP to APAP-GlcA (Danio rerio)
APAP [cytosol]
Metabolism (Danio rerio)
Biological oxidations (Danio rerio)
Phase II - Conjugation of compounds (Danio rerio)
Cytosolic sulfonation of small molecules (Danio rerio)
SULT1A1 dimer sulfonates PARA to PARA-SO4 (Danio rerio)
APAP [cytosol]
Metabolism of lipids (Danio rerio)
Fatty acid metabolism (Danio rerio)
Arachidonate metabolism (Danio rerio)
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Danio rerio)
PTGS1 dimer binds PTGS1 Inhibitors (Danio rerio)
PTGS1 Inhibitors [cytosol]
APAP [cytosol]
PTGS1 dimer:PTGS1 Inhibitors [endoplasmic reticulum membrane] (Danio rerio)
PTGS1 Inhibitors [cytosol]
APAP [cytosol]
PTGS1,2 dimers bind PTGS Inhibitors (Danio rerio)
PTGS inhibitors [cytosol]
APAP [cytosol]
PTGS1 dimer:PTGS Inhibitors [endoplasmic reticulum membrane] (Danio rerio)
PTGS inhibitors [cytosol]
APAP [cytosol]
PTGS2 dimer:PTGS inhibitors [endoplasmic reticulum membrane] (Danio rerio)
PTGS inhibitors [cytosol]
APAP [cytosol]
PTGS2 dimer binds PTGS inhibitors (Danio rerio)
PTGS inhibitors [cytosol]
APAP [cytosol]
PTGS2 dimer:PTGS inhibitors [endoplasmic reticulum membrane] (Danio rerio)
PTGS inhibitors [cytosol]
APAP [cytosol]
Drug ADME (Dictyostelium discoideum)
Paracetamol ADME (Dictyostelium discoideum)
CYP2E1 monooxygenates APAP to NAPQI (Dictyostelium discoideum)
APAP [cytosol]
Drug ADME (Drosophila melanogaster)
Paracetamol ADME (Drosophila melanogaster)
UGTs glucuronate APAP to APAP-GlcA (Drosophila melanogaster)
APAP [cytosol]
Drug ADME (Gallus gallus)
Paracetamol ADME (Gallus gallus)
CYP2E1 monooxygenates APAP to NAPQI (Gallus gallus)
APAP [cytosol]
SULT dimers sulfate APAP to APAP-SO3 (Gallus gallus)
APAP [cytosol]
UGTs glucuronate APAP to APAP-GlcA (Gallus gallus)
APAP [cytosol]
Metabolism (Gallus gallus)
Biological oxidations (Gallus gallus)
Phase II - Conjugation of compounds (Gallus gallus)
Cytosolic sulfonation of small molecules (Gallus gallus)
SULT1A1 dimer sulfonates PARA to PARA-SO4 (Gallus gallus)
APAP [cytosol]
Metabolism of lipids (Gallus gallus)
Fatty acid metabolism (Gallus gallus)
Arachidonate metabolism (Gallus gallus)
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Gallus gallus)
PTGS1 dimer binds PTGS1 Inhibitors (Gallus gallus)
PTGS1 Inhibitors [cytosol]
APAP [cytosol]
PTGS1 dimer:PTGS1 Inhibitors [endoplasmic reticulum membrane] (Gallus gallus)
PTGS1 Inhibitors [cytosol]
APAP [cytosol]
PTGS1,2 dimers bind PTGS Inhibitors (Gallus gallus)
PTGS inhibitors [cytosol]
APAP [cytosol]
PTGS1 dimer:PTGS Inhibitors [endoplasmic reticulum membrane] (Gallus gallus)
PTGS inhibitors [cytosol]
APAP [cytosol]
PTGS2 dimer:PTGS inhibitors [endoplasmic reticulum membrane] (Gallus gallus)
PTGS inhibitors [cytosol]
APAP [cytosol]
PTGS2 dimer binds PTGS inhibitors (Gallus gallus)
PTGS inhibitors [cytosol]
APAP [cytosol]
PTGS2 dimer:PTGS inhibitors [endoplasmic reticulum membrane] (Gallus gallus)
PTGS inhibitors [cytosol]
APAP [cytosol]
Drug ADME (Homo sapiens)
Paracetamol ADME (Homo sapiens)
APAP translocates from extracellular region to cytosol (Homo sapiens)
APAP [cytosol]
CYP2E1 monooxygenates APAP to NAPQI (Homo sapiens)
APAP [cytosol]
SULT dimers sulfate APAP to APAP-SO3 (Homo sapiens)
APAP [cytosol]
UGTs glucuronate APAP to APAP-GlcA (Homo sapiens)
APAP [cytosol]
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase II - Conjugation of compounds (Homo sapiens)
Cytosolic sulfonation of small molecules (Homo sapiens)
SULT1A1 dimer sulfonates PARA to PARA-SO4 (Homo sapiens)
APAP [cytosol]
Metabolism of lipids (Homo sapiens)
Fatty acid metabolism (Homo sapiens)
Arachidonate metabolism (Homo sapiens)
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Homo sapiens)
PTGS1 dimer binds PTGS1 Inhibitors (Homo sapiens)
PTGS1 Inhibitors [cytosol]
APAP [cytosol]
PTGS1 dimer:PTGS1 Inhibitors [endoplasmic reticulum membrane] (Homo sapiens)
PTGS1 Inhibitors [cytosol]
APAP [cytosol]
PTGS1,2 dimers bind PTGS Inhibitors (Homo sapiens)
PTGS inhibitors [cytosol]
APAP [cytosol]
PTGS1 dimer:PTGS Inhibitors [endoplasmic reticulum membrane] (Homo sapiens)
PTGS inhibitors [cytosol]
APAP [cytosol]
PTGS2 dimer:PTGS inhibitors [endoplasmic reticulum membrane] (Homo sapiens)
PTGS inhibitors [cytosol]
APAP [cytosol]
PTGS2 dimer binds PTGS inhibitors (Homo sapiens)
PTGS inhibitors [cytosol]
APAP [cytosol]
PTGS2 dimer:PTGS inhibitors [endoplasmic reticulum membrane] (Homo sapiens)
PTGS inhibitors [cytosol]
APAP [cytosol]
Drug ADME (Mus musculus)
Paracetamol ADME (Mus musculus)
CYP2E1 monooxygenates APAP to NAPQI (Mus musculus)
APAP [cytosol]
SULT dimers sulfate APAP to APAP-SO3 (Mus musculus)
APAP [cytosol]
UGTs glucuronate APAP to APAP-GlcA (Mus musculus)
APAP [cytosol]
Metabolism (Mus musculus)
Biological oxidations (Mus musculus)
Phase II - Conjugation of compounds (Mus musculus)
Cytosolic sulfonation of small molecules (Mus musculus)
SULT1A1 dimer sulfonates PARA to PARA-SO4 (Mus musculus)
APAP [cytosol]
Metabolism of lipids (Mus musculus)
Fatty acid metabolism (Mus musculus)
Arachidonate metabolism (Mus musculus)
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Mus musculus)
PTGS1 dimer binds PTGS1 Inhibitors (Mus musculus)
PTGS1 Inhibitors [cytosol]
APAP [cytosol]
PTGS1 dimer:PTGS1 Inhibitors [endoplasmic reticulum membrane] (Mus musculus)
PTGS1 Inhibitors [cytosol]
APAP [cytosol]
PTGS1,2 dimers bind PTGS Inhibitors (Mus musculus)
PTGS inhibitors [cytosol]
APAP [cytosol]
PTGS1 dimer:PTGS Inhibitors [endoplasmic reticulum membrane] (Mus musculus)
PTGS inhibitors [cytosol]
APAP [cytosol]
PTGS2 dimer:PTGS inhibitors [endoplasmic reticulum membrane] (Mus musculus)
PTGS inhibitors [cytosol]
APAP [cytosol]
PTGS2 dimer binds PTGS inhibitors (Mus musculus)
PTGS inhibitors [cytosol]
APAP [cytosol]
PTGS2 dimer:PTGS inhibitors [endoplasmic reticulum membrane] (Mus musculus)
PTGS inhibitors [cytosol]
APAP [cytosol]
Drug ADME (Rattus norvegicus)
Paracetamol ADME (Rattus norvegicus)
CYP2E1 monooxygenates APAP to NAPQI (Rattus norvegicus)
APAP [cytosol]
SULT dimers sulfate APAP to APAP-SO3 (Rattus norvegicus)
APAP [cytosol]
UGTs glucuronate APAP to APAP-GlcA (Rattus norvegicus)
APAP [cytosol]
Metabolism (Rattus norvegicus)
Biological oxidations (Rattus norvegicus)
Phase II - Conjugation of compounds (Rattus norvegicus)
Cytosolic sulfonation of small molecules (Rattus norvegicus)
SULT1A1 dimer sulfonates PARA to PARA-SO4 (Rattus norvegicus)
APAP [cytosol]
Metabolism of lipids (Rattus norvegicus)
Fatty acid metabolism (Rattus norvegicus)
Arachidonate metabolism (Rattus norvegicus)
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Rattus norvegicus)
PTGS1 dimer binds PTGS1 Inhibitors (Rattus norvegicus)
PTGS1 Inhibitors [cytosol]
APAP [cytosol]
PTGS1 dimer:PTGS1 Inhibitors [endoplasmic reticulum membrane] (Rattus norvegicus)
PTGS1 Inhibitors [cytosol]
APAP [cytosol]
PTGS1,2 dimers bind PTGS Inhibitors (Rattus norvegicus)
PTGS inhibitors [cytosol]
APAP [cytosol]
PTGS1 dimer:PTGS Inhibitors [endoplasmic reticulum membrane] (Rattus norvegicus)
PTGS inhibitors [cytosol]
APAP [cytosol]
PTGS2 dimer:PTGS inhibitors [endoplasmic reticulum membrane] (Rattus norvegicus)
PTGS inhibitors [cytosol]
APAP [cytosol]
PTGS2 dimer binds PTGS inhibitors (Rattus norvegicus)
PTGS inhibitors [cytosol]
APAP [cytosol]
PTGS2 dimer:PTGS inhibitors [endoplasmic reticulum membrane] (Rattus norvegicus)
PTGS inhibitors [cytosol]
APAP [cytosol]
Drug ADME (Sus scrofa)
Paracetamol ADME (Sus scrofa)
CYP2E1 monooxygenates APAP to NAPQI (Sus scrofa)
APAP [cytosol]
SULT dimers sulfate APAP to APAP-SO3 (Sus scrofa)
APAP [cytosol]
UGTs glucuronate APAP to APAP-GlcA (Sus scrofa)
APAP [cytosol]
Metabolism (Sus scrofa)
Biological oxidations (Sus scrofa)
Phase II - Conjugation of compounds (Sus scrofa)
Cytosolic sulfonation of small molecules (Sus scrofa)
SULT1A1 dimer sulfonates PARA to PARA-SO4 (Sus scrofa)
APAP [cytosol]
Metabolism of lipids (Sus scrofa)
Fatty acid metabolism (Sus scrofa)
Arachidonate metabolism (Sus scrofa)
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Sus scrofa)
PTGS1 dimer binds PTGS1 Inhibitors (Sus scrofa)
PTGS1 Inhibitors [cytosol]
APAP [cytosol]
PTGS1 dimer:PTGS1 Inhibitors [endoplasmic reticulum membrane] (Sus scrofa)
PTGS1 Inhibitors [cytosol]
APAP [cytosol]
PTGS1,2 dimers bind PTGS Inhibitors (Sus scrofa)
PTGS inhibitors [cytosol]
APAP [cytosol]
PTGS1 dimer:PTGS Inhibitors [endoplasmic reticulum membrane] (Sus scrofa)
PTGS inhibitors [cytosol]
APAP [cytosol]
PTGS2 dimer:PTGS inhibitors [endoplasmic reticulum membrane] (Sus scrofa)
PTGS inhibitors [cytosol]
APAP [cytosol]
PTGS2 dimer binds PTGS inhibitors (Sus scrofa)
PTGS inhibitors [cytosol]
APAP [cytosol]
PTGS2 dimer:PTGS inhibitors [endoplasmic reticulum membrane] (Sus scrofa)
PTGS inhibitors [cytosol]
APAP [cytosol]
Drug ADME (Xenopus tropicalis)
Paracetamol ADME (Xenopus tropicalis)
CYP2E1 monooxygenates APAP to NAPQI (Xenopus tropicalis)
APAP [cytosol]
SULT dimers sulfate APAP to APAP-SO3 (Xenopus tropicalis)
APAP [cytosol]
Metabolism (Xenopus tropicalis)
Biological oxidations (Xenopus tropicalis)
Phase II - Conjugation of compounds (Xenopus tropicalis)
Cytosolic sulfonation of small molecules (Xenopus tropicalis)
SULT1A1 dimer sulfonates PARA to PARA-SO4 (Xenopus tropicalis)
APAP [cytosol]
Metabolism of lipids (Xenopus tropicalis)
Fatty acid metabolism (Xenopus tropicalis)
Arachidonate metabolism (Xenopus tropicalis)
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Xenopus tropicalis)
PTGS1 dimer binds PTGS1 Inhibitors (Xenopus tropicalis)
PTGS1 Inhibitors [cytosol]
APAP [cytosol]
PTGS1 dimer:PTGS1 Inhibitors [endoplasmic reticulum membrane] (Xenopus tropicalis)
PTGS1 Inhibitors [cytosol]
APAP [cytosol]
PTGS1,2 dimers bind PTGS Inhibitors (Xenopus tropicalis)
PTGS inhibitors [cytosol]
APAP [cytosol]
PTGS1 dimer:PTGS Inhibitors [endoplasmic reticulum membrane] (Xenopus tropicalis)
PTGS inhibitors [cytosol]
APAP [cytosol]
PTGS2 dimer:PTGS inhibitors [endoplasmic reticulum membrane] (Xenopus tropicalis)
PTGS inhibitors [cytosol]
APAP [cytosol]
PTGS2 dimer binds PTGS inhibitors (Xenopus tropicalis)
PTGS inhibitors [cytosol]
APAP [cytosol]
PTGS2 dimer:PTGS inhibitors [endoplasmic reticulum membrane] (Xenopus tropicalis)
PTGS inhibitors [cytosol]
APAP [cytosol]
External Reference Information
External Reference
paracetamol [Guide to Pharmacology:5239]
Participates
as an input of
SULT1A1 dimer sulfonates PARA to PARA-SO4 (Homo sapiens)
SULT1A1 dimer sulfonates PARA to PARA-SO4 (Mus musculus)
SULT1A1 dimer sulfonates PARA to PARA-SO4 (Rattus norvegicus)
SULT1A1 dimer sulfonates PARA to PARA-SO4 (Canis familiaris)
SULT1A1 dimer sulfonates PARA to PARA-SO4 (Bos taurus)
SULT1A1 dimer sulfonates PARA to PARA-SO4 (Sus scrofa)
SULT1A1 dimer sulfonates PARA to PARA-SO4 (Danio rerio)
SULT1A1 dimer sulfonates PARA to PARA-SO4 (Xenopus tropicalis)
SULT1A1 dimer sulfonates PARA to PARA-SO4 (Gallus gallus)
CYP2E1 monooxygenates APAP to NAPQI (Homo sapiens)
CYP2E1 monooxygenates APAP to NAPQI (Mus musculus)
CYP2E1 monooxygenates APAP to NAPQI (Rattus norvegicus)
CYP2E1 monooxygenates APAP to NAPQI (Canis familiaris)
CYP2E1 monooxygenates APAP to NAPQI (Bos taurus)
CYP2E1 monooxygenates APAP to NAPQI (Sus scrofa)
CYP2E1 monooxygenates APAP to NAPQI (Danio rerio)
CYP2E1 monooxygenates APAP to NAPQI (Xenopus tropicalis)
CYP2E1 monooxygenates APAP to NAPQI (Gallus gallus)
CYP2E1 monooxygenates APAP to NAPQI (Caenorhabditis elegans)
CYP2E1 monooxygenates APAP to NAPQI (Dictyostelium discoideum)
SULT dimers sulfate APAP to APAP-SO3 (Homo sapiens)
SULT dimers sulfate APAP to APAP-SO3 (Mus musculus)
SULT dimers sulfate APAP to APAP-SO3 (Rattus norvegicus)
SULT dimers sulfate APAP to APAP-SO3 (Canis familiaris)
SULT dimers sulfate APAP to APAP-SO3 (Bos taurus)
SULT dimers sulfate APAP to APAP-SO3 (Sus scrofa)
SULT dimers sulfate APAP to APAP-SO3 (Danio rerio)
SULT dimers sulfate APAP to APAP-SO3 (Xenopus tropicalis)
SULT dimers sulfate APAP to APAP-SO3 (Gallus gallus)
SULT dimers sulfate APAP to APAP-SO3 (Caenorhabditis elegans)
UGTs glucuronate APAP to APAP-GlcA (Homo sapiens)
UGTs glucuronate APAP to APAP-GlcA (Mus musculus)
UGTs glucuronate APAP to APAP-GlcA (Rattus norvegicus)
UGTs glucuronate APAP to APAP-GlcA (Canis familiaris)
UGTs glucuronate APAP to APAP-GlcA (Bos taurus)
UGTs glucuronate APAP to APAP-GlcA (Sus scrofa)
UGTs glucuronate APAP to APAP-GlcA (Danio rerio)
UGTs glucuronate APAP to APAP-GlcA (Gallus gallus)
UGTs glucuronate APAP to APAP-GlcA (Drosophila melanogaster)
UGTs glucuronate APAP to APAP-GlcA (Caenorhabditis elegans)
as an output of
APAP translocates from extracellular region to cytosol (Homo sapiens)
as a member of
PTGS inhibitors [cytosol]
PTGS1 Inhibitors [cytosol]
Other forms of this molecule
APAP [extracellular region]
Disease
Name
Identifier
Synonyms
pain
SYMP:0000099
fever
SYMP:0000613
inflammation
SYMP:0000061
Cross References
ChEBI
46195
,
46195
Pharos - Ligands
W4WH4FK6P232
PubChem Compound
178101923
© 2026
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