SULT1A1 dimer sulfonates PARA to PARA-SO4

Stable Identifier
R-HSA-158468
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Acetaminophen can form an O- sulfate conjugate
Locations in the PathwayBrowser
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Cytosolic sulfotransferase 1A1 (SULT1A1), in dimeric form, can sulfonate the widely used analgesic and antipyretic drug paracetamol (PARA aka acetaminophen). Around 20-30% of PARA is metabolised via sulfonation by the liver (Parkinson 1995, Yamazoe et al. 1995, Strott 2002).

Literature References
PubMed ID Title Journal Year
12372849 Sulfonation and molecular action

Strott, CA

Endocr Rev 2002
  Casarett and Doull's Toxicology 5th Edn

Parkinson, A

  1995
10503886 Sulfotransferase catalyzing sulfation of heterocyclic amines

Yamazoe, Y, Nagata, K, Yoshinari, K, Fujita, K, Shiraga, T, Iwasaki, K

Cancer Lett 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
aryl sulfotransferase activity of SULT1A1 dimer [cytosol]
Physical Entity
Activity
Orthologous Events
Reviewed
Created
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