APAP translocates from extracellular region to cytosol

Stable Identifier
R-HSA-9754180
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
ReviewStatus
5/5
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APAP translocates from extracellular region to cytosol
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Paracetamol (APAP) is a weak acid (pKa ~9.5) so at physiological pH it is mostly neutral and can be rapidly absorbed from the duodenum into the bloodstream and from there into hepatocytes. The rate of gastric emptying can be used as a measure of plasma APAP levels (Nimmo et al. 1973, Heading et al. 1983). In humans, the half-life of APAP in blood after a therapeutic dose is 1.5hrs to 3hrs (Cummings et al. 1967).
Literature References
PubMed ID Title Journal Year
4694406 Pharmacological modification of gastric emptying: effects of propantheline and metoclopromide on paracetamol absorption

Nimmo, J, Prescott, LF, Heading, RC, Tothill, P

Br Med J 1973
6032053 A kinetic study of drug elimination: the excretion of paracetamol and its metabolites in man

Martin, BK, Cummings, AJ, King, ML

Br J Pharmacol Chemother 1967
4722050 The dependence of paracetamol absorption on the rate of gastric emptying

Nimmo, J, Prescott, LF, Heading, RC, Tothill, P

Br J Pharmacol 1973
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Authored
Jassal, B  (2021-09-21)
Reviewed
Huddart, R  (2021-10-13)
Created
Jassal, B  (2021-09-21)
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