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About
What is Reactome ?
News
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Table of Contents
DOIs
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Unmethylated CpG DNA [endosome membrane]
Stable Identifier
R-ALL-167913
Type
OtherEntity
Compartment
endosome membrane
Locations in the PathwayBrowser
for Species:
Homo sapiens
Canis familiaris
Danio rerio
Gallus gallus
Mus musculus
Rattus norvegicus
Sus scrofa
Xenopus tropicalis
Expand all
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
FLT3 Signaling (Canis familiaris)
PI3K Cascade (Canis familiaris)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Canis familiaris)
PI3K-containing complexes [cytosol] (Canis familiaris)
activated TLR9:PI3K class III [cytosol] (Canis familiaris)
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
Innate Immune System (Canis familiaris)
Toll-like Receptor Cascades (Canis familiaris)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 (Canis familiaris)
IRAK1/or IRAK2 :p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Canis familiaris)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Canis familiaris)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9. (Canis familiaris)
IRAK1/or IRAK2 :p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Canis familiaris)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 (Canis familiaris)
IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex (Canis familiaris)
IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9 (Canis familiaris)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Canis familiaris)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane] (Canis familiaris)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
MyD88 interacts with the activated TLR receptor 7, 8 or 9 (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
MyD88 complexed with the activated TLR receptor [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88 (Canis familiaris)
MyD88 complexed with the activated TLR receptor [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 (Canis familiaris)
IRAK2:p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane] (Canis familiaris)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane] (Canis familiaris)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9 (Canis familiaris)
p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Canis familiaris)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane] (Canis familiaris)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 (Canis familiaris)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Canis familiaris)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Canis familiaris)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Canis familiaris)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling (Canis familiaris)
Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation (Canis familiaris)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Canis familiaris)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Canis familiaris)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Canis familiaris)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Canis familiaris)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Canis familiaris)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation (Canis familiaris)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Canis familiaris)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Canis familiaris)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Canis familiaris)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Canis familiaris)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Canis familiaris)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex (Canis familiaris)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Canis familiaris)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Canis familiaris)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Canis familiaris)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane] (Canis familiaris)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Canis familiaris)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Canis familiaris)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex (Canis familiaris)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Canis familiaris)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Canis familiaris)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
Toll Like Receptor 9 (TLR9) Cascade (Canis familiaris)
Engulfed CpG DNA binds to endosomal C-ter TLR9 (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
N-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
Engulfed CpG DNA binds to endosomal full-length TLR9 (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
MyD88 dependent cascade initiated on endosome (Canis familiaris)
First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 (Canis familiaris)
IRAK1/or IRAK2 :p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Canis familiaris)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Canis familiaris)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9. (Canis familiaris)
IRAK1/or IRAK2 :p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Canis familiaris)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 (Canis familiaris)
IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex (Canis familiaris)
IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9 (Canis familiaris)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Canis familiaris)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane] (Canis familiaris)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
MyD88 interacts with the activated TLR receptor 7, 8 or 9 (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
MyD88 complexed with the activated TLR receptor [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88 (Canis familiaris)
MyD88 complexed with the activated TLR receptor [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 (Canis familiaris)
IRAK2:p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane] (Canis familiaris)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane] (Canis familiaris)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9 (Canis familiaris)
p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Canis familiaris)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane] (Canis familiaris)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 (Canis familiaris)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Canis familiaris)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Canis familiaris)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Canis familiaris)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling (Canis familiaris)
Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation (Canis familiaris)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Canis familiaris)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Canis familiaris)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Canis familiaris)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Canis familiaris)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Canis familiaris)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation (Canis familiaris)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Canis familiaris)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Canis familiaris)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Canis familiaris)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Canis familiaris)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Canis familiaris)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex (Canis familiaris)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Canis familiaris)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Canis familiaris)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Canis familiaris)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane] (Canis familiaris)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Canis familiaris)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Canis familiaris)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex (Canis familiaris)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Canis familiaris)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Canis familiaris)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Canis familiaris)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Canis familiaris)
Activated TLR7-9 homodimers [endosome membrane] (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
Rab5-mediated recruitment of class III PI3K to TLR9 (Canis familiaris)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
activated TLR9:PI3K class III [cytosol] (Canis familiaris)
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
Signal Transduction (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by Insulin receptor (Canis familiaris)
Insulin receptor signalling cascade (Canis familiaris)
IRS-mediated signalling (Canis familiaris)
PI3K Cascade (Canis familiaris)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Canis familiaris)
PI3K-containing complexes [cytosol] (Canis familiaris)
activated TLR9:PI3K class III [cytosol] (Canis familiaris)
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Canis familiaris)
IGF1R signaling cascade (Canis familiaris)
IRS-related events triggered by IGF1R (Canis familiaris)
IRS-mediated signalling (Canis familiaris)
PI3K Cascade (Canis familiaris)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Canis familiaris)
PI3K-containing complexes [cytosol] (Canis familiaris)
activated TLR9:PI3K class III [cytosol] (Canis familiaris)
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Canis familiaris)
Unmethylated CpG DNA [endosome membrane]
Immune System (Danio rerio)
Cytokine Signaling in Immune system (Danio rerio)
FLT3 Signaling (Danio rerio)
PI3K Cascade (Danio rerio)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Danio rerio)
PI3K-containing complexes [cytosol] (Danio rerio)
activated TLR9:PI3K class III [cytosol] (Danio rerio)
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
Innate Immune System (Danio rerio)
Toll-like Receptor Cascades (Danio rerio)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Danio rerio)
MyD88 dependent cascade initiated on endosome (Danio rerio)
First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 (Danio rerio)
IRAK1:p-S,2T-IRAK4 :oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Danio rerio)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Danio rerio)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9. (Danio rerio)
IRAK1/or IRAK2 :p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Danio rerio)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 (Danio rerio)
IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex (Danio rerio)
IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9 (Danio rerio)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Danio rerio)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane] (Danio rerio)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
MyD88 interacts with the activated TLR receptor 7, 8 or 9 (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
MyD88 complexed with the activated TLR receptor [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88 (Danio rerio)
MyD88 complexed with the activated TLR receptor [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 (Danio rerio)
IRAK2:p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane] (Danio rerio)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane] (Danio rerio)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9 (Danio rerio)
p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Danio rerio)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane] (Danio rerio)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 (Danio rerio)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Danio rerio)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Danio rerio)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Danio rerio)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling (Danio rerio)
Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation (Danio rerio)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Danio rerio)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Danio rerio)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Danio rerio)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Danio rerio)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Danio rerio)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation (Danio rerio)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Danio rerio)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Danio rerio)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Danio rerio)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Danio rerio)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Danio rerio)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex (Danio rerio)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Danio rerio)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Danio rerio)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Danio rerio)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane] (Danio rerio)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Danio rerio)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Danio rerio)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Danio rerio)
Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex (Danio rerio)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Danio rerio)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Danio rerio)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
Toll Like Receptor 9 (TLR9) Cascade (Danio rerio)
Engulfed CpG DNA binds to endosomal C-ter TLR9 (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
N-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
Engulfed CpG DNA binds to endosomal full-length TLR9 (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
MyD88 dependent cascade initiated on endosome (Danio rerio)
First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 (Danio rerio)
IRAK1:p-S,2T-IRAK4 :oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Danio rerio)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Danio rerio)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9. (Danio rerio)
IRAK1/or IRAK2 :p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Danio rerio)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 (Danio rerio)
IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex (Danio rerio)
IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9 (Danio rerio)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Danio rerio)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane] (Danio rerio)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
MyD88 interacts with the activated TLR receptor 7, 8 or 9 (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
MyD88 complexed with the activated TLR receptor [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88 (Danio rerio)
MyD88 complexed with the activated TLR receptor [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 (Danio rerio)
IRAK2:p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane] (Danio rerio)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane] (Danio rerio)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9 (Danio rerio)
p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Danio rerio)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane] (Danio rerio)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 (Danio rerio)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Danio rerio)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Danio rerio)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Danio rerio)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling (Danio rerio)
Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation (Danio rerio)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Danio rerio)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Danio rerio)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Danio rerio)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Danio rerio)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Danio rerio)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation (Danio rerio)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Danio rerio)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Danio rerio)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Danio rerio)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Danio rerio)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Danio rerio)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex (Danio rerio)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Danio rerio)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Danio rerio)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Danio rerio)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane] (Danio rerio)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Danio rerio)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Danio rerio)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Danio rerio)
Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex (Danio rerio)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Danio rerio)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Danio rerio)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Danio rerio)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Danio rerio)
Activated TLR7-9 homodimers [endosome membrane] (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
Rab5-mediated recruitment of class III PI3K to TLR9 (Danio rerio)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
activated TLR9:PI3K class III [cytosol] (Danio rerio)
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
Signal Transduction (Danio rerio)
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by Insulin receptor (Danio rerio)
Insulin receptor signalling cascade (Danio rerio)
IRS-mediated signalling (Danio rerio)
PI3K Cascade (Danio rerio)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Danio rerio)
PI3K-containing complexes [cytosol] (Danio rerio)
activated TLR9:PI3K class III [cytosol] (Danio rerio)
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Danio rerio)
IGF1R signaling cascade (Danio rerio)
IRS-related events triggered by IGF1R (Danio rerio)
IRS-mediated signalling (Danio rerio)
PI3K Cascade (Danio rerio)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Danio rerio)
PI3K-containing complexes [cytosol] (Danio rerio)
activated TLR9:PI3K class III [cytosol] (Danio rerio)
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Danio rerio)
Unmethylated CpG DNA [endosome membrane]
Innate Immune System (Gallus gallus)
Toll-like receptors (TLR) cascades (Gallus gallus)
TLR21 cascade (Gallus gallus)
MyD88-dependent cascade initiated on endosome membrane (Gallus gallus)
Activated TLR7 or 21 recruits MyD88 (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
Autophosphorylation of IRAK4 bound to the activated TLR7 or 21complex. (Gallus gallus)
activated TLR7/or TLR21 : MyD88 : IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
IRAK2 binds to p-IRAK4:MyD88:activated TLR7 or 21 complex (Gallus gallus)
IRAK2:p-IRAK4:MyD88:activated TLR7 /or 21 complex [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21 : MyD88 : IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
IRAK2 phosphorylation bound to the activated TLR7 (or TLR21) complex (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
IRAK2:p-IRAK4:MyD88:activated TLR7 /or 21 complex [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21 : MyD88 : IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
IRAK4 binds to the activated TLR7 or 21 (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
activated TLR7/or TLR21 : MyD88 : IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation (Gallus gallus)
Activated TAK1 leaves endosome membrane (Gallus gallus)
p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [cytosol] (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [endosome membrane] (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
Activated TRAF6 recruits TAK1 kinase complex upon TLR7 or TLR21 stimulation (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
p-IRAK2:oligo pUb TRAF6 : TAK1 :TAB1 : TAB2/TAB3 : free K63 pUb chains [endosome membrane] (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
Activated TRAF6 synthesizes free K63 linked pUb chains. (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1 upon TLR7 or 21 stimulation (Gallus gallus)
p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [endosome membrane] (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
p-IRAK2:oligo pUb TRAF6 : TAK1 :TAB1 : TAB2/TAB3 : free K63 pUb chains [endosome membrane] (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
Autoubiquitination of oligoTRAF6 bound to p-IRAK2 (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
TRAF6 binds to p-IRAK2 complexed with activated TLR7 or TLR21 (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
TRAF6 bound to activated TLR7 or 21 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
p-IRAK2- TRAF6 dissociates from the activated TRL7 or 21 (Gallus gallus)
TRAF6 bound to activated TLR7 or 21 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
TLR21homodimer binds to DNA (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
TLR7 cascade (Gallus gallus)
MyD88-dependent cascade initiated on endosome membrane (Gallus gallus)
Activated TLR7 or 21 recruits MyD88 (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
Autophosphorylation of IRAK4 bound to the activated TLR7 or 21complex. (Gallus gallus)
activated TLR7/or TLR21 : MyD88 : IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
IRAK2 binds to p-IRAK4:MyD88:activated TLR7 or 21 complex (Gallus gallus)
IRAK2:p-IRAK4:MyD88:activated TLR7 /or 21 complex [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21 : MyD88 : IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
IRAK2 phosphorylation bound to the activated TLR7 (or TLR21) complex (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
IRAK2:p-IRAK4:MyD88:activated TLR7 /or 21 complex [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21 : MyD88 : IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
IRAK4 binds to the activated TLR7 or 21 (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
activated TLR7/or TLR21 : MyD88 : IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation (Gallus gallus)
Activated TAK1 leaves endosome membrane (Gallus gallus)
p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [cytosol] (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [endosome membrane] (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
Activated TRAF6 recruits TAK1 kinase complex upon TLR7 or TLR21 stimulation (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
p-IRAK2:oligo pUb TRAF6 : TAK1 :TAB1 : TAB2/TAB3 : free K63 pUb chains [endosome membrane] (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
Activated TRAF6 synthesizes free K63 linked pUb chains. (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1 upon TLR7 or 21 stimulation (Gallus gallus)
p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [endosome membrane] (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
p-IRAK2:oligo pUb TRAF6 : TAK1 :TAB1 : TAB2/TAB3 : free K63 pUb chains [endosome membrane] (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
Autoubiquitination of oligoTRAF6 bound to p-IRAK2 (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
TRAF6 binds to p-IRAK2 complexed with activated TLR7 or TLR21 (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
TRAF6 bound to activated TLR7 or 21 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
p-IRAK2- TRAF6 dissociates from the activated TRL7 or 21 (Gallus gallus)
TRAF6 bound to activated TLR7 or 21 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7 or 21 bound to ligand [endosome membrane] (Gallus gallus)
TLR21 bound to unmethylated CpG DNA [endosome membrane] (Gallus gallus)
Unmethylated CpG DNA [endosome membrane]
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
FLT3 Signaling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI3K-containing complexes [cytosol] (Homo sapiens)
activated TLR9:PI3K class III [cytosol] (Homo sapiens)
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 (Homo sapiens)
IRAK1:p-S,2T-IRAK4 :oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9. (Homo sapiens)
IRAK1/or IRAK2 :p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 (Homo sapiens)
IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex (Homo sapiens)
IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9 (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
MyD88 interacts with the activated TLR receptor 7, 8 or 9 (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
MyD88 complexed with the activated TLR receptor [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88 (Homo sapiens)
MyD88 complexed with the activated TLR receptor [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 (Homo sapiens)
IRAK2:p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9 (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 (Homo sapiens)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling (Homo sapiens)
Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation (Homo sapiens)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation (Homo sapiens)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex (Homo sapiens)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex (Homo sapiens)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
Engulfed CpG DNA binds to endosomal C-ter TLR9 (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
N-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
Engulfed CpG DNA binds to endosomal full-length TLR9 (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
MyD88 dependent cascade initiated on endosome (Homo sapiens)
First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 (Homo sapiens)
IRAK1:p-S,2T-IRAK4 :oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9. (Homo sapiens)
IRAK1/or IRAK2 :p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 (Homo sapiens)
IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex (Homo sapiens)
IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9 (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
MyD88 interacts with the activated TLR receptor 7, 8 or 9 (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
MyD88 complexed with the activated TLR receptor [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88 (Homo sapiens)
MyD88 complexed with the activated TLR receptor [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 (Homo sapiens)
IRAK2:p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9 (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 (Homo sapiens)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling (Homo sapiens)
Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation (Homo sapiens)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation (Homo sapiens)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex (Homo sapiens)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex (Homo sapiens)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
Rab5-mediated recruitment of class III PI3K to TLR9 (Homo sapiens)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
activated TLR9:PI3K class III [cytosol] (Homo sapiens)
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by Insulin receptor (Homo sapiens)
Insulin receptor signalling cascade (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI3K-containing complexes [cytosol] (Homo sapiens)
activated TLR9:PI3K class III [cytosol] (Homo sapiens)
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
IGF1R signaling cascade (Homo sapiens)
IRS-related events triggered by IGF1R (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI3K-containing complexes [cytosol] (Homo sapiens)
activated TLR9:PI3K class III [cytosol] (Homo sapiens)
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Homo sapiens)
Unmethylated CpG DNA [endosome membrane]
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
FLT3 Signaling (Mus musculus)
PI3K Cascade (Mus musculus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Mus musculus)
PI3K-containing complexes [cytosol] (Mus musculus)
activated TLR9:PI3K class III [cytosol] (Mus musculus)
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
Innate Immune System (Mus musculus)
Toll-like Receptor Cascades (Mus musculus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 (Mus musculus)
IRAK1:p-S,2T-IRAK4 :oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Mus musculus)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Mus musculus)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Mus musculus)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Mus musculus)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9. (Mus musculus)
IRAK1/or IRAK2 :p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Mus musculus)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Mus musculus)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Mus musculus)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 (Mus musculus)
IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Mus musculus)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Mus musculus)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex (Mus musculus)
IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Mus musculus)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9 (Mus musculus)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Mus musculus)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Mus musculus)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane] (Mus musculus)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Mus musculus)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
MyD88 interacts with the activated TLR receptor 7, 8 or 9 (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
MyD88 complexed with the activated TLR receptor [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88 (Mus musculus)
MyD88 complexed with the activated TLR receptor [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 (Mus musculus)
IRAK2:p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane] (Mus musculus)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Mus musculus)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane] (Mus musculus)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Mus musculus)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9 (Mus musculus)
p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Mus musculus)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Mus musculus)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane] (Mus musculus)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Mus musculus)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 (Mus musculus)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Mus musculus)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Mus musculus)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Mus musculus)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Mus musculus)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Mus musculus)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling (Mus musculus)
Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation (Mus musculus)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Mus musculus)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Mus musculus)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Mus musculus)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Mus musculus)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Mus musculus)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Mus musculus)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Mus musculus)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation (Mus musculus)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Mus musculus)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Mus musculus)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Mus musculus)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Mus musculus)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Mus musculus)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Mus musculus)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Mus musculus)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex (Mus musculus)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Mus musculus)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Mus musculus)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Mus musculus)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Mus musculus)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
Toll Like Receptor 9 (TLR9) Cascade (Mus musculus)
Engulfed CpG DNA binds to endosomal C-ter TLR9 (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
N-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
Engulfed CpG DNA binds to endosomal full-length TLR9 (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
MyD88 dependent cascade initiated on endosome (Mus musculus)
First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 (Mus musculus)
IRAK1:p-S,2T-IRAK4 :oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Mus musculus)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Mus musculus)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Mus musculus)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Mus musculus)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9. (Mus musculus)
IRAK1/or IRAK2 :p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Mus musculus)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Mus musculus)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Mus musculus)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 (Mus musculus)
IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Mus musculus)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Mus musculus)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex (Mus musculus)
IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Mus musculus)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9 (Mus musculus)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Mus musculus)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Mus musculus)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane] (Mus musculus)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Mus musculus)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
MyD88 interacts with the activated TLR receptor 7, 8 or 9 (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
MyD88 complexed with the activated TLR receptor [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88 (Mus musculus)
MyD88 complexed with the activated TLR receptor [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 (Mus musculus)
IRAK2:p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane] (Mus musculus)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Mus musculus)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane] (Mus musculus)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Mus musculus)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9 (Mus musculus)
p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Mus musculus)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Mus musculus)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane] (Mus musculus)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Mus musculus)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 (Mus musculus)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Mus musculus)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Mus musculus)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Mus musculus)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Mus musculus)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Mus musculus)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling (Mus musculus)
Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation (Mus musculus)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Mus musculus)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Mus musculus)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Mus musculus)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Mus musculus)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Mus musculus)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Mus musculus)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Mus musculus)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation (Mus musculus)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Mus musculus)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Mus musculus)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Mus musculus)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Mus musculus)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Mus musculus)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Mus musculus)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Mus musculus)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex (Mus musculus)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Mus musculus)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Mus musculus)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Mus musculus)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Mus musculus)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Mus musculus)
Activated TLR7-9 homodimers [endosome membrane] (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
Rab5-mediated recruitment of class III PI3K to TLR9 (Mus musculus)
C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
activated TLR9:PI3K class III [cytosol] (Mus musculus)
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
Signal Transduction (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by Insulin receptor (Mus musculus)
Insulin receptor signalling cascade (Mus musculus)
IRS-mediated signalling (Mus musculus)
PI3K Cascade (Mus musculus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Mus musculus)
PI3K-containing complexes [cytosol] (Mus musculus)
activated TLR9:PI3K class III [cytosol] (Mus musculus)
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Mus musculus)
IGF1R signaling cascade (Mus musculus)
IRS-related events triggered by IGF1R (Mus musculus)
IRS-mediated signalling (Mus musculus)
PI3K Cascade (Mus musculus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Mus musculus)
PI3K-containing complexes [cytosol] (Mus musculus)
activated TLR9:PI3K class III [cytosol] (Mus musculus)
fl-TLR9:unmethylated CpG DNA [endosome membrane] (Mus musculus)
Unmethylated CpG DNA [endosome membrane]
