Engulfed CpG DNA binds to endosomal full-length TLR9

Stable Identifier
R-HSA-1679589
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Both the full-length receptor and cleaved fragment corresponding to the C-terminal part of TLR9 were capable to bind ligand, however only processed form (TLR9 C-ter, aa 471-1032) was shown to bind MyD88 and induce signaling in different mouse cells (Ewald SE et al 2008,).

Literature References
PubMed ID Title Journal Year
18820679 The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor

Ewald, SE, Lee, BL, Lau, L, Wickliffe, KE, Shi, GP, Chapman, HA, Barton, GM

Nature 2008
15207506 The immunobiology of the TLR9 subfamily

Wagner, H

Trends Immunol 2004
21604257 Negative regulation of signaling by a soluble form of toll-like receptor 9

Chockalingam, A, Cameron, JL, Brooks, JC, Leifer, CA

Eur J Immunol 2011
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Orthologous Events
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