Both the full-length receptor and cleaved fragment corresponding to the C-terminal part of TLR9 were capable to bind ligand, however only processed form (TLR9 C-ter, aa 471-1032) was shown to bind MyD88 and induce signaling in different mouse cells (Ewald SE et al 2008,).
Wagner, H
Barton, GM, Wickliffe, KE, Ewald, SE, Chapman, HA, Lau, L, Lee, BL, Shi, GP
Cameron, JL, Brooks, JC, Chockalingam, A, Leifer, CA
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