Both the full-length receptor and cleaved fragment corresponding to the C-terminal part of TLR9 were capable to bind ligand, however only processed form (TLR9 C-ter, aa 471-1032) was shown to bind MyD88 and induce signaling in different mouse cells (Ewald SE et al 2008,).
Barton, GM, Wickliffe, KE, Ewald, SE, Chapman, HA, Lau, L, Lee, BL, Shi, GP
Wagner, H
Cameron, JL, Brooks, JC, Chockalingam, A, Leifer, CA
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