Engulfed CpG DNA binds to endosomal full-length TLR9

Stable Identifier
R-HSA-1679589
Type
Reaction [binding]
Species
Homo sapiens
Compartment
endosome membrane
ReviewStatus
5/5
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Engulfed CpG DNA binds to endosomal full-length TLR9
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Both the full-length receptor and cleaved fragment corresponding to the C-terminal part of TLR9 were capable to bind ligand, however only processed form (TLR9 C-ter, aa 471-1032) was shown to bind MyD88 and induce signaling in different mouse cells (Ewald SE et al 2008,).
Literature References
PubMed ID Title Journal Year
15207506 The immunobiology of the TLR9 subfamily

Wagner, H

Trends Immunol 2004
18820679 The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor

Ewald, SE, Lee, BL, Lau, L, Wickliffe, KE, Shi, GP, Chapman, HA, Barton, GM

Nature 2008
21604257 Negative regulation of signaling by a soluble form of toll-like receptor 9

Chockalingam, A, Cameron, JL, Brooks, JC, Leifer, CA

Eur J Immunol 2011
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Orthologous Events
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Authored
Shamovsky, V  (2011-09-21)
Reviewed
Gillespie, ME  (2012-02-09)
Created
Shamovsky, V  (2011-10-20)
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