Reactome | Engulfed CpG DNA binds to endosomal full-length TLR9

Engulfed CpG DNA binds to endosomal full-length TLR9

Stable Identifier

R-HSA-1679589

Type

Reaction [binding]

Species

Homo sapiens

Compartment

endosome membrane

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Engulfed CpG DNA binds to endosomal full-length TLR9

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Both the full-length receptor and cleaved fragment corresponding to the C-terminal part of TLR9 were capable to bind ligand, however only processed form (TLR9 C-ter, aa 471-1032) was shown to bind MyD88 and induce signaling in different mouse cells (Ewald SE et al 2008,).

Literature References

PubMed ID	Title	Journal	Year
18820679	The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor Ewald, SE, Lee, BL, Lau, L, Wickliffe, KE, Shi, GP, Chapman, HA, Barton, GM	Nature	2008
15207506	The immunobiology of the TLR9 subfamily Wagner, H	Trends Immunol	2004
21604257	Negative regulation of signaling by a soluble form of toll-like receptor 9 Chockalingam, A, Cameron, JL, Brooks, JC, Leifer, CA	Eur J Immunol	2011