Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer

Stable Identifier
R-HSA-1679098
Type
Reaction [binding]
Species
Homo sapiens
Compartment
endosome membrane
ReviewStatus
5/5
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Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer
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TLR9 traffics to an endosomal vesicle where it is processed by cathepsin S at neural pH to generate an N-terminal product (TLR9 N-ter, aa 1-723). The N-terminal fragment of TLR9 also binds ligand, but in contrast to the C-terminal fragment it inhibits TLR9 signaling. Thus, a proper balance between the two proteolytic events probably regulates TLR9-mediated host responses. (Chockalingam A et al 2011).
Literature References
PubMed ID Title Journal Year
15207506 The immunobiology of the TLR9 subfamily

Wagner, H

Trends Immunol 2004
21604257 Negative regulation of signaling by a soluble form of toll-like receptor 9

Cameron, JL, Brooks, JC, Chockalingam, A, Leifer, CA

Eur J Immunol 2011
Participants
Input
Output
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as an event of
This event is regulated
Positively by
Regulator
EEA1:EEA1 [endosome membrane] (Homo sapiens)
Orthologous Events
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Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Mus musculus)
Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Rattus norvegicus)
Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Sus scrofa)
Authored
Shamovsky, V  (2011-09-21)
Reviewed
Gillespie, ME  (2012-02-09)
Created
Shamovsky, V  (2011-10-19)
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