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KDM6B binds iron
Stable Identifier
R-HSA-8979071
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Oxidative Stress Induced Senescence (Homo sapiens)
KDM6B binds iron (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
KDM6B (JMJD3) binds iron. Formation of complex with Fe(II) is needed for the catalytic activity of KDM6B (De Santa et al. 2007).
Literature References
PubMed ID
Title
Journal
Year
17825402
The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing
Testa, G
,
Notarbartolo, S
,
Prosperini, E
,
De Santa, F
,
Natoli, G
,
Totaro, MG
Cell
2007
Participants
Input
Fe2+ [nucleoplasm]
KDM6B [nucleoplasm]
(Homo sapiens)
Output
KDM6B:Fe2+ [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Oxidative Stress Induced Senescence (Homo sapiens)
Orthologous Events
KDM6B binds iron (Bos taurus)
KDM6B binds iron (Caenorhabditis elegans)
KDM6B binds iron (Canis familiaris)
KDM6B binds iron (Dictyostelium discoideum)
KDM6B binds iron (Drosophila melanogaster)
KDM6B binds iron (Mus musculus)
KDM6B binds iron (Rattus norvegicus)
KDM6B binds iron (Saccharomyces cerevisiae)
KDM6B binds iron (Schizosaccharomyces pombe)
KDM6B binds iron (Sus scrofa)
KDM6B binds iron (Xenopus tropicalis)
Authored
Orlic-Milacic, M (2013-07-15)
Reviewed
Samarajiwa, S (2013-09-03)
Created
Orlic-Milacic, M (2017-02-21)
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