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1,25(OH)2D [cytosol]
Stable Identifier
R-ALL-209800
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
CTL, calcitriol, 1,25-dihydroxyD3, 1,25-dihydroxyvitamin D3
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Drosophila melanogaster
Mus musculus
Rattus norvegicus
Sus scrofa
Expand all
Metabolism (Bos taurus)
Biological oxidations (Bos taurus)
Phase I - Functionalization of compounds (Bos taurus)
Cytochrome P450 - arranged by substrate type (Bos taurus)
Vitamins (Bos taurus)
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Bos taurus)
1,25(OH)2D [cytosol]
Metabolism of lipids (Bos taurus)
Metabolism of steroids (Bos taurus)
Vitamin D (calciferol) metabolism (Bos taurus)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Bos taurus)
1,25(OH)2D [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Bos taurus)
1,25(OH)2D [cytosol]
Metabolism (Caenorhabditis elegans)
Metabolism of lipids (Caenorhabditis elegans)
Metabolism of steroids (Caenorhabditis elegans)
Vitamin D (calciferol) metabolism (Caenorhabditis elegans)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Caenorhabditis elegans)
1,25(OH)2D [cytosol]
Metabolism (Canis familiaris)
Biological oxidations (Canis familiaris)
Phase I - Functionalization of compounds (Canis familiaris)
Cytochrome P450 - arranged by substrate type (Canis familiaris)
Vitamins (Canis familiaris)
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Canis familiaris)
1,25(OH)2D [cytosol]
Metabolism of lipids (Canis familiaris)
Metabolism of steroids (Canis familiaris)
Vitamin D (calciferol) metabolism (Canis familiaris)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Canis familiaris)
1,25(OH)2D [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Canis familiaris)
1,25(OH)2D [cytosol]
Metabolism (Danio rerio)
Biological oxidations (Danio rerio)
Phase I - Functionalization of compounds (Danio rerio)
Cytochrome P450 - arranged by substrate type (Danio rerio)
Vitamins (Danio rerio)
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Danio rerio)
1,25(OH)2D [cytosol]
Metabolism of lipids (Danio rerio)
Metabolism of steroids (Danio rerio)
Vitamin D (calciferol) metabolism (Danio rerio)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Danio rerio)
1,25(OH)2D [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Danio rerio)
1,25(OH)2D [cytosol]
Metabolism (Drosophila melanogaster)
Metabolism of lipids (Drosophila melanogaster)
Metabolism of steroids (Drosophila melanogaster)
Vitamin D (calciferol) metabolism (Drosophila melanogaster)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Drosophila melanogaster)
1,25(OH)2D [cytosol]
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase I - Functionalization of compounds (Homo sapiens)
Cytochrome P450 - arranged by substrate type (Homo sapiens)
Vitamins (Homo sapiens)
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Homo sapiens)
1,25(OH)2D [cytosol]
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Vitamin D (calciferol) metabolism (Homo sapiens)
1,25(OH)2D translocates from cytosol to nucleoplasm (Homo sapiens)
1,25(OH)2D [cytosol]
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Homo sapiens)
1,25(OH)2D [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Homo sapiens)
1,25(OH)2D [cytosol]
Metabolism (Mus musculus)
Biological oxidations (Mus musculus)
Phase I - Functionalization of compounds (Mus musculus)
Cytochrome P450 - arranged by substrate type (Mus musculus)
Vitamins (Mus musculus)
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Mus musculus)
1,25(OH)2D [cytosol]
Metabolism of lipids (Mus musculus)
Metabolism of steroids (Mus musculus)
Vitamin D (calciferol) metabolism (Mus musculus)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Mus musculus)
1,25(OH)2D [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Mus musculus)
1,25(OH)2D [cytosol]
Metabolism (Rattus norvegicus)
Biological oxidations (Rattus norvegicus)
Phase I - Functionalization of compounds (Rattus norvegicus)
Cytochrome P450 - arranged by substrate type (Rattus norvegicus)
Vitamins (Rattus norvegicus)
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Rattus norvegicus)
1,25(OH)2D [cytosol]
Metabolism of lipids (Rattus norvegicus)
Metabolism of steroids (Rattus norvegicus)
Vitamin D (calciferol) metabolism (Rattus norvegicus)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Rattus norvegicus)
1,25(OH)2D [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Rattus norvegicus)
1,25(OH)2D [cytosol]
Metabolism (Sus scrofa)
Biological oxidations (Sus scrofa)
Phase I - Functionalization of compounds (Sus scrofa)
Cytochrome P450 - arranged by substrate type (Sus scrofa)
Vitamins (Sus scrofa)
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Sus scrofa)
1,25(OH)2D [cytosol]
Metabolism of lipids (Sus scrofa)
Metabolism of steroids (Sus scrofa)
Vitamin D (calciferol) metabolism (Sus scrofa)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Sus scrofa)
1,25(OH)2D [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Sus scrofa)
1,25(OH)2D [cytosol]
External Reference Information
External Reference
calcitriol [ChEBI:17823]
Participates
as an input of
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Caenorhabditis elegans)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Drosophila melanogaster)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Danio rerio)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Sus scrofa)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Canis familiaris)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Rattus norvegicus)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Mus musculus)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Homo sapiens)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Bos taurus)
1,25(OH)2D translocates from cytosol to nucleoplasm (Homo sapiens)
as an output of
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Danio rerio)
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Sus scrofa)
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Bos taurus)
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Canis familiaris)
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Rattus norvegicus)
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Mus musculus)
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Homo sapiens)
Other forms of this molecule
CTL [mitochondrial matrix]
1,25(OH)2D [nucleoplasm]
Cross References
Guide to Pharmacology - Ligands
2779
COMPOUND
C01673
HMDB Metabolite
HMDB0001903
ZINC
ZINC000100015048
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