CYP24A1 hydroxylates 1,25(OH)2D, inactivating it

Stable Identifier
R-HSA-209765
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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1-alpha, 25-dihydroxyvitamin D (1,25(OH)2D) is biologically inactivated through a series of reactions beginning with 24-hydroxylation and is most likely a mechanism of elimination. 24-Hydroxylation of vitamin D metabolites is largely regulated inversely to 1-hydroxylation, the initial step towards activation (Chen et al. 1993).

Literature References
PubMed ID Title Journal Year
8506296 Isolation and expression of human 1,25-dihydroxyvitamin D3 24-hydroxylase cDNA

Chen, KS, Prahl, JM, DeLuca, HF

Proc Natl Acad Sci U S A 1993
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Catalyst Activity
Title
1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity of CYP24A1 [mitochondrial inner membrane]
Physical Entity
Activity
Orthologous Events
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