1,25(OH)2D translocates from cytosol to nucleoplasm

Stable Identifier
R-HSA-8963913
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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1,25(OH)2D translocates from cytosol to nucleoplasm
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The biologically active form of vitamin D, 1-alpha, 25-dihydroxyvitamin D (1,25(OH)2D), can be transported to any target tissue where it enters the nucleoplasm to interact with vitamin D receptor (VDR) to exert its effects. The mechanism of translocation from cytosol to nucleoplasm is unknown (see review for general description - Christakos et al. 2016).
Literature References
PubMed ID Title Journal Year
26681795 Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects

Carmeliet, G, Christakos, S, Dhawan, P, Verlinden, L, Verstuyf, A

Physiol. Rev. 2016
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Output
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as an event of
Authored
Jassal, B  (2017-02-14)
Reviewed
Holick, F  (2017-11-09)
Created
Jassal, B  (2017-02-14)
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