Unfortunately, installation of a local Neo4J server can be complicated due to variations in individual setup (computer, operating system, version of Neo4J and so forth). 

Please follow this guide to install the graph database locally, there are different ways to install the graph database, and we also provide graph tar file and dump file to meet different requirements.

As a long-term solution to this issue, we are working on providing the Neo4J databases in Docker containers. When these are ready for deployment, they will be added to the Reactome Download page.

In the meantime, if you are getting an error message that the database is unavailable, please feel free to contact our developers through the help email (This email address is being protected from spambots. You need JavaScript enabled to view it.) and we will try to assist you.