Reactome | POLRMT polymerizes RNA primer for mitochondrial L strand replication

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POLRMT polymerizes RNA primer for mitochondrial L strand replication Show undefined attributes

catalystActivity	[CatalystActivity:10726861] DNA-directed RNA polymerase activity of POLRMT:POLG:PEO1:OriL:Mitochondrial H strand replisome:H strand RNA primer:nascent H strand DNA [mitochondrial matrix]
category	omitted
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10726863
displayName	POLRMT polymerizes RNA primer for mitochondrial L strand replication
eventOf	[Pathway:R-XTR-9913635] Strand-asynchronous mitochondrial DNA replication - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-XTR-9914498] POLG in the replisome polymerizes the L strand - Xenopus tropicalis
inferredFrom	[BlackBoxEvent:R-HSA-9914409] POLRMT polymerizes RNA primer for mitochondrial L strand replication - Homo sapiens
input	[SimpleEntity:R-ALL-113593] ATP [mitochondrial matrix] [SimpleEntity:R-ALL-110577] CTP [mitochondrial matrix] [SimpleEntity:R-ALL-113573] GTP [mitochondrial matrix] [Complex:R-XTR-9914388] POLRMT:POLG:PEO1:OriL:Mitochondrial H strand replisome:H strand RNA primer:nascent H strand DNA [mitochondrial matrix] [SimpleEntity:R-ALL-110731] UTP [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	POLRMT polymerizes RNA primer for mitochondrial L strand replication
output	[Complex:R-XTR-9914373] L strand primer:Mitochondrial L strand replisome:Mitochondrial H strand replisome:H strand RNA primer:nascent H strand DNA [mitochondrial matrix] [EntityWithAccessionedSequence:R-XTR-163267] polrmt [mitochondrial matrix] [SimpleEntity:R-ALL-159450] PPi [mitochondrial matrix]
precedingEvent	[Reaction:R-XTR-9914404] POLRMT and POLG bind the mitochondrial L strand replication origin (OriL) - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-9914409
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-9913635] Strand-asynchronous mitochondrial DNA replication
(precedingEvent)	[BlackBoxEvent:R-XTR-9914498] POLG in the replisome polymerizes the L strand
(inferredTo)	[BlackBoxEvent:R-HSA-9914409] POLRMT polymerizes RNA primer for mitochondrial L strand replication