Reactome | POLRMT and POLG bind the mitochondrial L strand replication origin (OriL)

Schema > Reaction > Entries

POLRMT and POLG bind the mitochondrial L strand replication origin (OriL) Show undefined attributes

category	binding
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10726856
displayName	POLRMT and POLG bind the mitochondrial L strand replication origin (OriL)
eventOf	[Pathway:R-XTR-9913635] Strand-asynchronous mitochondrial DNA replication - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-XTR-9914409] POLRMT polymerizes RNA primer for mitochondrial L strand replication - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-9914404] POLRMT and POLG bind the mitochondrial L strand replication origin (OriL) - Homo sapiens
input	[Complex:R-XTR-9913642] POLG:POLG2 [mitochondrial matrix] [EntityWithAccessionedSequence:R-XTR-163267] polrmt [mitochondrial matrix] [Complex:R-XTR-9914497] SSBP1:Mitochondrial H strand replisome:H strand RNA primer:nascent H strand [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	POLRMT and POLG bind the mitochondrial L strand replication origin (OriL)
output	[Complex:R-XTR-9914388] POLRMT:POLG:PEO1:OriL:Mitochondrial H strand replisome:H strand RNA primer:nascent H strand DNA [mitochondrial matrix]
precedingEvent	[Reaction:R-XTR-9914478] SSBP1 binds the displaced parental H strand - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-9914404
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-9913635] Strand-asynchronous mitochondrial DNA replication
(precedingEvent)	[BlackBoxEvent:R-XTR-9914409] POLRMT polymerizes RNA primer for mitochondrial L strand replication
(inferredTo)	[Reaction:R-HSA-9914404] POLRMT and POLG bind the mitochondrial L strand replication origin (OriL)

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