Reactome | 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane]

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2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-XTR-8854978] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] - Xenopus tropicalis [Complex:R-XTR-8854399] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [plasma membrane] - Xenopus tropicalis
consumedByEvent	[BlackBoxEvent:R-XTR-8853793] p-5Y-RET complexes bind GRB2 - Xenopus tropicalis [Reaction:R-XTR-8853734] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 - Xenopus tropicalis
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10701415
displayName	2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane]
hasComponent	[Complex:R-XTR-8854160] 2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] [GenomeEncodedEntity:R-XTR-912321] Ghost homologue of p-Y349,Y350,Y427-SHC1 [cytosol]
inDisease	false
inferredFrom	[DefinedSet:R-HSA-8854900] p-5Y-RET:GDNF:GFRA complexes with and without p-SHC1 [plasma membrane] - Homo sapiens [Complex:R-HSA-8854980] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] - Homo sapiens
maxDepth	3
name	2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1
producedByEvent	[BlackBoxEvent:R-XTR-8854981] SHC1 in the RET complex is phosphorylated - Xenopus tropicalis
schemaClass	Complex
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-8854980
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(input)	[BlackBoxEvent:R-XTR-8853793] p-5Y-RET complexes bind GRB2 [Reaction:R-XTR-8853734] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1
(hasComponent)	[Complex:R-XTR-8854978] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] [Complex:R-XTR-8854399] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [plasma membrane]
(inferredTo)	[DefinedSet:R-HSA-8854900] p-5Y-RET:GDNF:GFRA complexes with and without p-SHC1 [plasma membrane] [Complex:R-HSA-8854980] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane]
(output)	[BlackBoxEvent:R-XTR-8854981] SHC1 in the RET complex is phosphorylated

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