Reactome | 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [plasma membrane]

Schema > Complex > Entries

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10701417
displayName	2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [plasma membrane]
hasComponent	[Complex:R-XTR-8854980] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] [Complex:R-XTR-109797] GRB2-1:SOS1 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-8854399] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [plasma membrane] - Homo sapiens
maxDepth	4
memberOf	[DefinedSet:R-XTR-5672601] RAS GEFs [plasma membrane] - Xenopus tropicalis
name	2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1
producedByEvent	[Reaction:R-XTR-8853734] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 - Xenopus tropicalis
schemaClass	Complex
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-8854399
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(output)	[Reaction:R-XTR-8853734] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1
(hasMember)	[DefinedSet:R-XTR-5672601] RAS GEFs [plasma membrane]
(inferredTo)	[Complex:R-HSA-8854399] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [plasma membrane]

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