Reactome | 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane]

2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane]

Stable Identifier

R-XTR-8854980

Type

Complex

Species

Xenopus tropicalis

Compartment

plasma membrane

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General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Xenopus tropicalis)
Ghost homologue of p-Y349,Y350,Y427-SHC1 [cytosol] (Xenopus tropicalis)

Participates

as an input of

p-5Y-RET complexes bind GRB2 (Xenopus tropicalis)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Xenopus tropicalis)

as a component of

2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Xenopus tropicalis)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [plasma membrane] (Xenopus tropicalis)

as an output of

SHC1 in the RET complex is phosphorylated (Xenopus tropicalis)

Inferred From

p-5Y-RET:GDNF:GFRA complexes with and without p-SHC1 [plasma membrane] (Homo sapiens)

2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Homo sapiens)