Reactome | Caspase activation via extrinsic apoptotic signalling pathway

Schema > Pathway > Entries

created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10729708
displayName	Caspase activation via extrinsic apoptotic signalling pathway
eventOf	[Pathway:R-XTR-109581] Apoptosis - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:2133498] extrinsic apoptotic signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-XTR-418889] Caspase activation via Dependence Receptors in the absence of ligand - Xenopus tropicalis
inferredFrom	[Pathway:R-HSA-5357769] Caspase activation via extrinsic apoptotic signalling pathway - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Caspase activation via extrinsic apoptotic signalling pathway
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-5357769
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-XTR-109581] Apoptosis
(inferredTo)	[Pathway:R-HSA-5357769] Caspase activation via extrinsic apoptotic signalling pathway

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