Reactome | leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1]

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leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] Show undefined attributes

catalystActivity	[CatalystActivity:10652911] branched-chain-amino-acid transaminase activity of BCAT1 dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10652913
displayName	leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1]
eventOf	[Pathway:R-XTR-70895] Branched-chain amino acid catabolism - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-9859148] BCKDHA:BCKDHB tetramer decarboxylates KIC, KMVA, KIV - Xenopus tropicalis [Reaction:R-XTR-210444] L-Glutamate loading of synaptic vesicle - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-70723] leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] - Homo sapiens
input	[SimpleEntity:R-ALL-29406] 2OG [cytosol] [DefinedSet:R-ALL-508182] Leu, Ile, Val [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] 2-oxoglutarate + L-leucine => 4-methyl-2-oxopentanoate + L-glutamate 2-oxoglutarate + L-isoleucine => (S)-3-methyl-2-oxopentanoate + L-glutamate 2-oxoglutarate + L-valine => 3-methyl-2-oxobutanoate + L-glutamate
output	[DefinedSet:R-ALL-508187] KIC,KMVA,KIV [cytosol] [SimpleEntity:R-ALL-29404] L-Glu [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-70723
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-XTR-210444] L-Glutamate loading of synaptic vesicle [Reaction:R-XTR-9859148] BCKDHA:BCKDHB tetramer decarboxylates KIC, KMVA, KIV
(hasEvent)	[Pathway:R-XTR-70895] Branched-chain amino acid catabolism
(inferredTo)	[Reaction:R-HSA-70723] leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1]

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