Reactome | G2/M DNA damage checkpoint

Schema > Pathway > Entries

created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10729192
displayName	G2/M DNA damage checkpoint
eventOf	[Pathway:R-XTR-69481] G2/M Checkpoints - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-XTR-5683774] p-T68-CHEK2 dimerizes - Xenopus tropicalis [Reaction:R-XTR-5683792] p-T68-CHEK2 autophosphorylates - Xenopus tropicalis [Pathway:R-XTR-75035] Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex - Xenopus tropicalis
inferredFrom	[Pathway:R-HSA-69473] G2/M DNA damage checkpoint - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	G2/M DNA damage checkpoint
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-69473
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-XTR-69481] G2/M Checkpoints
(inferredTo)	[Pathway:R-HSA-69473] G2/M DNA damage checkpoint

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