Reactome | ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA

Schema > Reaction > Entries

ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA Show undefined attributes

catalystActivity	[CatalystActivity:10703655] helicase activity of Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10703657
displayName	ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA
eventOf	[Pathway:R-XTR-5696395] Formation of Incision Complex in GG-NER - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-6790454] SUMOylation of XPC - Xenopus tropicalis
goBiologicalProcess	[GO_BiologicalProcess:436508] global genome nucleotide-excision repair
inferredFrom	[Reaction:R-HSA-5690996] ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-XTR-5696652] Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [SimpleEntity:R-ALL-113550] Pi [nucleoplasm] [Complex:R-XTR-5691018] Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-5690996
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-5696395] Formation of Incision Complex in GG-NER
(precedingEvent)	[Reaction:R-XTR-6790454] SUMOylation of XPC
(inferredTo)	[Reaction:R-HSA-5690996] ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA

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