Reactome | ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA

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ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA Show undefined attributes

authored	[InstanceEdit:73956] Joshi-Tope, G, 2003-07-14 15:01:00 [InstanceEdit:110275] Hoeijmakers, JH, 2004-01-29 18:08:33 [InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16
catalystActivity	[CatalystActivity:5691030] helicase activity of Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5690995] Orlic-Milacic, Marija, 2015-05-04
dbId	5690996
deleted	[Deleted:6793213] Deletion of instance: 73934
displayName	ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA
edited	[InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16
eventOf	[Pathway:R-HSA-5696395] Formation of Incision Complex in GG-NER - Homo sapiens
followingEvent	[Reaction:R-HSA-6790454] SUMOylation of XPC - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:436508] global genome nucleotide-excision repair
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-5696652] Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5689301] Novel functional interactions between nucleotide excision DNA repair proteins influencing the enzymatic activities of TFIIH, XPG, and ERCC1-XPF [LiteratureReference:5689311] Distinct roles for the XPB/p52 and XPD/p44 subcomplexes of TFIIH in damaged DNA opening during nucleotide excision repair [LiteratureReference:5689302] Functional and structural studies of the nucleotide excision repair helicase XPD suggest a polarity for DNA translocation [LiteratureReference:5689306] Molecular insights into the recruitment of TFIIH to sites of DNA damage [LiteratureReference:5689305] Strand- and site-specific DNA lesion demarcation by the xeroderma pigmentosum group D helicase [LiteratureReference:5689489] DNA quality control by a lesion sensor pocket of the xeroderma pigmentosum group D helicase subunit of TFIIH [LiteratureReference:5689491] Recognition of helical kinks by xeroderma pigmentosum group A protein triggers DNA excision repair [LiteratureReference:5689497] Two-step recognition of DNA damage for mammalian nucleotide excision repair: Directional binding of the XPC complex and DNA strand scanning
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA
orthologousEvent	[Reaction:R-MMU-5690996] ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA - Mus musculus [Reaction:R-PFA-5690996] ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA - Plasmodium falciparum [Reaction:R-SPO-5690996] ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA - Schizosaccharomyces pombe [Reaction:R-DDI-5690996] ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA - Dictyostelium discoideum [Reaction:R-CEL-5690996] ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA - Caenorhabditis elegans [Reaction:R-DME-5690996] ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA - Drosophila melanogaster [Reaction:R-GGA-5690996] ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA - Gallus gallus [Reaction:R-XTR-5690996] ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA - Xenopus tropicalis [Reaction:R-DRE-5690996] ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA - Danio rerio [Reaction:R-SSC-5690996] ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA - Sus scrofa [Reaction:R-BTA-5690996] ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA - Bos taurus [Reaction:R-CFA-5690996] ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA - Canis familiaris [Reaction:R-RNO-5690996] ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA - Rattus norvegicus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [SimpleEntity:R-ALL-113550] Pi [nucleoplasm] [Complex:R-HSA-5691018] Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5696670] CHD1L is recruited to GG-NER site - Homo sapiens
releaseDate	2004-03-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6790576] Fousteri, Maria, 2015-08-03
revised	[InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5690996
summation	[Summation:5690977] Two DNA helicases XPB (ERCC3) and XPD (ERCC2), which are par...

Referrals

(replacementInstances)	[Deleted:6793213] Deletion of instance: 73934
(hasEvent)	[Pathway:R-HSA-5696395] Formation of Incision Complex in GG-NER
(precedingEvent)	[Reaction:R-HSA-6790454] SUMOylation of XPC

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