Reactome | PARP1,PARP2 dimers [nucleoplasm]

Schema > Complex > Entries

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-XTR-5649866] PARP1,PARP2:FEN1:POLB:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] - Xenopus tropicalis [Complex:R-XTR-5687643] Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] - Xenopus tropicalis [Complex:R-XTR-5687514] Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] - Xenopus tropicalis
consumedByEvent	[Reaction:R-XTR-5696664] PARP1 or PARP2 binds DDB2 at GG-NER site - Xenopus tropicalis [Reaction:R-XTR-5649873] PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site - Xenopus tropicalis [Reaction:R-XTR-5687484] PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site - Xenopus tropicalis
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10700150
displayName	PARP1,PARP2 dimers [nucleoplasm]
hasComponent	2 × [EntityWithAccessionedSequence:R-XTR-201568] parp1 [nucleoplasm]
inDisease	false
inferredFrom	[Complex:R-HSA-5649884] PARP1,PARP2 dimers [nucleoplasm] - Homo sapiens
maxDepth	2
name	PARP1,PARP2 dimers
producedByEvent	[Reaction:R-XTR-5651828] PARG dePARylates PARP1,PARP2 - Xenopus tropicalis
schemaClass	Complex
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-5649884
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(output)	[Reaction:R-XTR-5651828] PARG dePARylates PARP1,PARP2
(activeUnit)	[CatalystActivity:10700195] NAD+ poly-ADP-ribosyltransferase activity of PARP1,PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] [CatalystActivity:10702602] NAD+ poly-ADP-ribosyltransferase activity of Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm]
(input)	[Reaction:R-XTR-5649873] PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site [Reaction:R-XTR-5696664] PARP1 or PARP2 binds DDB2 at GG-NER site [Reaction:R-XTR-5687484] PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site
(hasComponent)	[Complex:R-XTR-5649866] PARP1,PARP2:FEN1:POLB:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] [Complex:R-XTR-5649888] PARP1,PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] [Complex:R-XTR-5696660] Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2 [nucleoplasm] [Complex:R-XTR-5687514] Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] [Complex:R-XTR-5687643] Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm]
(inferredTo)	[Complex:R-HSA-5649884] PARP1,PARP2 dimers [nucleoplasm]

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