Reactome | secretion of WNT ligands

Schema > Reaction > Entries

secretion of WNT ligands Show undefined attributes

category	dissociation
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10486564] Wright, Adam, 2024-03-07
dbId	10526087
displayName	secretion of WNT ligands
eventOf	[Pathway:R-XTR-3238698] WNT ligand biogenesis and trafficking - Xenopus tropicalis
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-XTR-3247847] WLS is endocytosed to the early endosome - Xenopus tropicalis [Reaction:R-XTR-5099899] WNT5A binds FZD4 - Xenopus tropicalis [Reaction:R-XTR-5140741] WNT5A binds FZD and ROR receptors - Xenopus tropicalis [Reaction:R-XTR-5099886] WNT5A binding to FZD promotes PRICKLE1 degradation - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-3247843] secretion of WNT ligands - Homo sapiens
input	[Complex:R-XTR-3247838] WLS:WNT [plasma membrane]
isInDisease	false
isInferred	true
name	secretion of WNT ligands
output	[EntityWithAccessionedSequence:R-XTR-3247746] wls [plasma membrane] [DefinedSet:R-XTR-3247835] WNTs [extracellular region]
precedingEvent	[BlackBoxEvent:R-XTR-3247844] WNT ligands traffic to the plasma membrane - Xenopus tropicalis
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-3247843
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-3238698] WNT ligand biogenesis and trafficking
(precedingEvent)	[BlackBoxEvent:R-XTR-3247847] WLS is endocytosed to the early endosome [Reaction:R-XTR-5099899] WNT5A binds FZD4 [Reaction:R-XTR-5140741] WNT5A binds FZD and ROR receptors [Reaction:R-XTR-5099886] WNT5A binding to FZD promotes PRICKLE1 degradation
(inferredTo)	[Reaction:R-HSA-3247843] secretion of WNT ligands