Reactome | acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial]

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acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] Show undefined attributes

catalystActivity	[CatalystActivity:10676081] acetate-CoA ligase activity of ACSS1 [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10676083
displayName	acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial]
eventOf	[Pathway:R-XTR-71384] Ethanol oxidation - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-449911] acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] - Homo sapiens
input	[SimpleEntity:R-ALL-113593] ATP [mitochondrial matrix] [SimpleEntity:R-ALL-113539] CH3COO- [mitochondrial matrix] [SimpleEntity:R-ALL-29374] CoA-SH [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial]
output	[SimpleEntity:R-ALL-113559] Ac-CoA [mitochondrial matrix] [SimpleEntity:R-ALL-159448] AMP [mitochondrial matrix] [SimpleEntity:R-ALL-159450] PPi [mitochondrial matrix]
precedingEvent	[Reaction:R-XTR-71723] acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-449911
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-71384] Ethanol oxidation
(inferredTo)	[Reaction:R-HSA-449911] acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial]

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