Reactome | TAK1 complex [cytosol]

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TAK1 complex [cytosol] Show undefined attributes

catalystActivities	[CatalystActivity:10677543] MAP kinase kinase kinase activity of TAK1 complex [cytosol]
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-XTR-5607672] p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TRIKA2 [plasma membrane] - Xenopus tropicalis [Complex:R-XTR-2685689] DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6:TAK1:TAB1:TAB2/3 [plasma membrane] - Xenopus tropicalis
consumedByEvent	[Reaction:R-XTR-5607759] TRIKA2 binds K63polyUb-TRAF6 oligomer - Xenopus tropicalis [Reaction:R-XTR-9645406] ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) - Xenopus tropicalis [Reaction:R-XTR-9645406] ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) - Xenopus tropicalis [Reaction:R-XTR-2730861] Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 - Xenopus tropicalis
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10675754
displayName	TAK1 complex [cytosol]
hasComponent	[EntityWithAccessionedSequence:R-XTR-168156] MAP3K7 [cytosol] [EntityWithAccessionedSequence:R-XTR-167923] tab1 [cytosol] [DefinedSet:R-XTR-446874] TAB2,TAB3 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-450277] TAB1:TAB2,TAB3:TAK1 [cytosol] - Homo sapiens [Complex:R-HSA-446878] TAK1 complex [cytosol] - Homo sapiens
maxDepth	3
name	TAK1 complex
schemaClass	Complex
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-446878
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(input)	[Reaction:R-XTR-5607759] TRIKA2 binds K63polyUb-TRAF6 oligomer [Reaction:R-XTR-2730861] Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 [Reaction:R-XTR-9645406] ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1)
(hasComponent)	[Complex:R-XTR-5607672] p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TRIKA2 [plasma membrane] [Complex:R-XTR-2685689] DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6:TAK1:TAB1:TAB2/3 [plasma membrane] [Complex:R-XTR-450185] hp-IRAK1:K6-poly-Ub oligo-TRAF6:TAK1 complex [cytosol] [Complex:R-XTR-936953] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] [Complex:R-XTR-706477] PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol]
(physicalEntity)	[CatalystActivity:10677543] MAP kinase kinase kinase activity of TAK1 complex [cytosol]
(inferredTo)	[Complex:R-HSA-450277] TAB1:TAB2,TAB3:TAK1 [cytosol] [Complex:R-HSA-446878] TAK1 complex [cytosol]

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