Reactome | CCR4-NOT complex deadenylates mRNA

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CCR4-NOT complex deadenylates mRNA Show undefined attributes

catalystActivity	[CatalystActivity:10674457] poly(A)-specific ribonuclease activity of CCR4-NOT Complex [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10674459
displayName	CCR4-NOT complex deadenylates mRNA
eventOf	[Pathway:R-XTR-429947] Deadenylation of mRNA - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-429978] Lsm1-7 Complex binds deadenylated mRNA - Xenopus tropicalis [Reaction:R-XTR-430028] Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-429955] CCR4-NOT complex deadenylates mRNA - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-XTR-429989] Partially Deadenylated mRNA Complex [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CCR4-NOT complex deadenylates mRNA
output	[SimpleEntity:R-ALL-76577] AMP [cytosol] [EntityWithAccessionedSequence:R-XTR-927868] EIF4A3 [cytosol] [EntityWithAccessionedSequence:R-XTR-72589] eif4b [cytosol] [EntityWithAccessionedSequence:R-XTR-72578] eif4e [cytosol] [EntityWithAccessionedSequence:R-XTR-72584] eif4g1 [cytosol] [OtherEntity:R-ALL-429974] mature mRNA (eukaryotic, capped and deadenylated) [cytosol] [EntityWithAccessionedSequence:R-XTR-156803] pabpc1 [cytosol] [EntityWithAccessionedSequence:R-XTR-429861] paip1 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-429955
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-429947] Deadenylation of mRNA
(precedingEvent)	[Reaction:R-XTR-429978] Lsm1-7 Complex binds deadenylated mRNA [Reaction:R-XTR-430028] Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion
(inferredTo)	[Reaction:R-HSA-429955] CCR4-NOT complex deadenylates mRNA