Reactome | EGF-like ligands:p-6Y EGFR dimer [plasma membrane]

Schema > Complex > Entries

EGF-like ligands:p-6Y EGFR dimer [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-XTR-182928] EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] - Xenopus tropicalis [Complex:R-XTR-180503] EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] - Xenopus tropicalis
consumedByEvent	[Reaction:R-XTR-177943] GRB2:SOS1 complex binds to EGF:EGFR complex - Xenopus tropicalis [Reaction:R-XTR-212706] Phospholipase C-gamma1 binds to the activated EGF receptor - Xenopus tropicalis [Reaction:R-XTR-177941] GRB2:GAB1 binds to phosphorylated EGFR - Xenopus tropicalis
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10662596
displayName	EGF-like ligands:p-6Y EGFR dimer [plasma membrane]
hasComponent	2 × [DefinedSet:R-XTR-9624194] EGF-like ligands [extracellular region] 2 × [EntityWithAccessionedSequence:R-XTR-179803] phospho-p-6Y-EGFR [plasma membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane] - Homo sapiens
maxDepth	3
name	EGF-like ligands:p-6Y EGFR dimer
producedByEvent	[Reaction:R-XTR-212713] Active PLC-gamma1 dissociates from EGFR - Xenopus tropicalis [Reaction:R-XTR-177934] EGFR autophosphorylation - Xenopus tropicalis [Reaction:R-XTR-177937] Phosphorylation of EGFR by SRC kinase - Xenopus tropicalis
schemaClass	Complex
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-9624425
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(hasComponent)	[Complex:R-XTR-182928] EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] [Complex:R-XTR-182960] EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] [Complex:R-XTR-180503] EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] [Complex:R-XTR-9624427] EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] [Complex:R-XTR-179820] EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] [Complex:R-XTR-180337] EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] [Complex:R-XTR-212717] EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] [Complex:R-XTR-212703] EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] [Complex:R-XTR-180348] EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] [Complex:R-XTR-180286] EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane]
(input)	[Reaction:R-XTR-177943] GRB2:SOS1 complex binds to EGF:EGFR complex [Reaction:R-XTR-212706] Phospholipase C-gamma1 binds to the activated EGF receptor [Reaction:R-XTR-177941] GRB2:GAB1 binds to phosphorylated EGFR
(output)	[Reaction:R-XTR-212713] Active PLC-gamma1 dissociates from EGFR [Reaction:R-XTR-177934] EGFR autophosphorylation [Reaction:R-XTR-177937] Phosphorylation of EGFR by SRC kinase
(inferredTo)	[Complex:R-HSA-9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane]

© 2026 Reactome

Cite Us!