Reactome | Tie2 Signaling

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Tie2 Signaling Show undefined attributes

created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10729590
displayName	Tie2 Signaling
eventOf	[Pathway:R-XTR-202733] Cell surface interactions at the vascular wall - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-XTR-204779] Interaction of Tie2 with Ang1 - Xenopus tropicalis [Reaction:R-XTR-210881] Dimerization of Tie2/Ang1 complex - Xenopus tropicalis [Reaction:R-XTR-204798] Interaction of Tie2 and p85 of PI3K - Xenopus tropicalis [Reaction:R-XTR-204871] Interaction of Tie2 and Grb2 - Xenopus tropicalis [Reaction:R-XTR-210974] Interaction of SOS-1 to Tie2 bound Grb2 - Xenopus tropicalis [Reaction:R-XTR-210977] Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) - Xenopus tropicalis [Reaction:R-XTR-204850] Interaction of Tie2 and Dok-2 - Xenopus tropicalis [Reaction:R-XTR-204863] Interaction of Tie2 with Ang2 - Xenopus tropicalis [Reaction:R-XTR-204873] Interaction of Tie2 and Shp2 - Xenopus tropicalis [Reaction:R-XTR-204773] Interaction of Tie2 and Grb7 - Xenopus tropicalis
inferredFrom	[Pathway:R-HSA-210993] Tie2 Signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Tie2 Signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-210993
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-202733] Cell surface interactions at the vascular wall
(inferredTo)	[Pathway:R-HSA-210993] Tie2 Signaling

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