Reactome | Thyroxine biosynthesis

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Thyroxine biosynthesis Show undefined attributes

created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10729606
displayName	Thyroxine biosynthesis
eventOf	[Pathway:R-XTR-209776] Metabolism of amine-derived hormones - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:19403] thyroid hormone generation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-XTR-209910] Iodide is taken up by thyroid epithelial cells - Xenopus tropicalis [Reaction:R-XTR-5693681] DUOX1 reduces O2 to H2O2 - Xenopus tropicalis [Reaction:R-XTR-350901] Iodide is organified - Xenopus tropicalis [Reaction:R-XTR-209815] Tyrosine is monoiodinated - Xenopus tropicalis [Reaction:R-XTR-209921] Monoiodinated tyrosine can be deiodinated - Xenopus tropicalis [Reaction:R-XTR-209973] Tyrosine is diiodinated - Xenopus tropicalis [Reaction:R-XTR-209960] Diiodinated tyrosine can be deiodinated - Xenopus tropicalis [Reaction:R-XTR-209925] DIT and MIT combine to form triiodothyronine - Xenopus tropicalis [Reaction:R-XTR-209840] Two DITs combine to form thyroxine - Xenopus tropicalis [Pathway:R-XTR-350864] Regulation of thyroid hormone activity - Xenopus tropicalis
inferredFrom	[Pathway:R-HSA-209968] Thyroxine biosynthesis - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Thyroxine biosynthesis
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-209968
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-209776] Metabolism of amine-derived hormones
(inferredTo)	[Pathway:R-HSA-209968] Thyroxine biosynthesis

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