Reactome | Regulation of thyroid hormone activity

Schema > Pathway > Entries

created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10729604
displayName	Regulation of thyroid hormone activity
eventOf	[Pathway:R-XTR-209968] Thyroxine biosynthesis - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:12039] thyroid hormone metabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-XTR-209772] Thyroxine is deiodinated to triiodothyronine - Xenopus tropicalis [Reaction:R-XTR-350869] Thyroxine is deiodinated to reverse triiodothyronine (RT3) - Xenopus tropicalis
inferredFrom	[Pathway:R-HSA-350864] Regulation of thyroid hormone activity - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Regulation of thyroid hormone activity
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-350864
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-XTR-209968] Thyroxine biosynthesis
(inferredTo)	[Pathway:R-HSA-350864] Regulation of thyroid hormone activity

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