Reactome | p-2S-SMAD1/5/8:SMAD4 [nucleoplasm]

Schema > Complex > Entries

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-XTR-201427] p-2S-SMAD1/5/8:SMAD4:SKI [nucleoplasm] - Xenopus tropicalis
consumedByEvent	[Reaction:R-XTR-201423] SKI complexes with the Smad complex, suppressing BMP2 signalling - Xenopus tropicalis
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10665375
displayName	p-2S-SMAD1/5/8:SMAD4 [nucleoplasm]
hasComponent	2 × [DefinedSet:R-XTR-201444] Phospho-R-SMAD1/5/9 [nucleoplasm] [EntityWithAccessionedSequence:R-XTR-177103] smad4 [nucleoplasm]
inDisease	false
inferredFrom	[Complex:R-HSA-201450] p-2S-SMAD1/5/8:SMAD4 [nucleoplasm] - Homo sapiens
maxDepth	3
name	p-2S-SMAD1/5/8:SMAD4
producedByEvent	[Reaction:R-XTR-201472] The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus - Xenopus tropicalis
schemaClass	Complex
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-201450
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-XTR-201423] SKI complexes with the Smad complex, suppressing BMP2 signalling
(hasComponent)	[Complex:R-XTR-201427] p-2S-SMAD1/5/8:SMAD4:SKI [nucleoplasm]
(output)	[Reaction:R-XTR-201472] The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus
(inferredTo)	[Complex:R-HSA-201450] p-2S-SMAD1/5/8:SMAD4 [nucleoplasm]

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