Reactome | Cyclin A:Cdk2 mediated phosphorylation of p27/p21

Schema > Reaction > Entries

Cyclin A:Cdk2 mediated phosphorylation of p27/p21 Show undefined attributes

catalystActivity	[CatalystActivity:10663052] cyclin-dependent protein serine/threonine kinase activity of Cyclin A:Cdk2:p21/p27 complex [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10663054
displayName	Cyclin A:Cdk2 mediated phosphorylation of p27/p21
eventOf	[Pathway:R-XTR-69656] Cyclin A:Cdk2-associated events at S phase entry - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-187916] Cyclin A:Cdk2 mediated phosphorylation of p27/p21 - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-XTR-187926] Cyclin A:Cdk2:p21/p27 complex [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Cyclin A:Cdk2 mediated phosphorylation of p27/p21
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-XTR-187912] Cyclin A:Cdk2:phospho-p27/p21 complex [nucleoplasm]
precedingEvent	[Reaction:R-XTR-187949] CAK-mediated phosphorylation of Cyclin A:Cdk2 - Xenopus tropicalis [Reaction:R-XTR-187934] Inactivation of Cyclin A:Cdk2 complexes by p27/p21 - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-187916
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-69656] Cyclin A:Cdk2-associated events at S phase entry
(inferredTo)	[Reaction:R-HSA-187916] Cyclin A:Cdk2 mediated phosphorylation of p27/p21

Cite Us!