Reactome | Cyclin A:Cdk2-associated events at S phase entry

Schema > Pathway > Entries

Cyclin A:Cdk2-associated events at S phase entry Show undefined attributes

created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10729240
displayName	Cyclin A:Cdk2-associated events at S phase entry
eventOf	[Pathway:R-XTR-69242] S Phase - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:24606] positive regulation of DNA replication
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-XTR-174054] Formation of Cyclin A:Cdk2 complexes - Xenopus tropicalis [Reaction:R-XTR-174273] Translocation of Cyclin A:Cdk2 complexes to the nucleus - Xenopus tropicalis [Reaction:R-XTR-187828] Translocation of p21 to the nucleus - Xenopus tropicalis [Reaction:R-XTR-187506] Translocation of p27 to the nucleoplasm - Xenopus tropicalis [Pathway:R-XTR-187577] SCF(Skp2)-mediated degradation of p27/p21 - Xenopus tropicalis [Reaction:R-XTR-174164] Phosphorylation of Cyclin A:Cdk2 at Tyr 15 - Xenopus tropicalis [Reaction:R-XTR-174110] Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 - Xenopus tropicalis [Reaction:R-XTR-187949] CAK-mediated phosphorylation of Cyclin A:Cdk2 - Xenopus tropicalis [Reaction:R-XTR-187916] Cyclin A:Cdk2 mediated phosphorylation of p27/p21 - Xenopus tropicalis [Reaction:R-XTR-187934] Inactivation of Cyclin A:Cdk2 complexes by p27/p21 - Xenopus tropicalis [Reaction:R-XTR-187948] Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 - Xenopus tropicalis
inferredFrom	[Pathway:R-HSA-69656] Cyclin A:Cdk2-associated events at S phase entry - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Cyclin A:Cdk2-associated events at S phase entry
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-69656
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-69242] S Phase
(inferredTo)	[Pathway:R-HSA-69656] Cyclin A:Cdk2-associated events at S phase entry

© 2026 Reactome

Cite Us!