Reactome | phospho-ppp1r1b [cytosol]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-XTR-180025] Phosphorylated (T34) DARPP-32:PP1A [cytosol] - Xenopus tropicalis
consumedByEvent	[Reaction:R-XTR-180038] DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function - Xenopus tropicalis
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10662459
displayName	phospho-ppp1r1b [cytosol]
endCoordinate	204
hasModifiedResidue	[ModifiedResidue:10662457] O-phospho-L-threonine at 34 (in Homo sapiens)
inDisease	false
inferredFrom	[DefinedSet:R-HSA-180075] DARPP-32 phosphorylated on T34 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-177274] p-T34-PPP1R1B [cytosol] - Homo sapiens
maxDepth	1
name	phospho-ppp1r1b p-T34-PPP1R1B A4II07
producedByEvent	[Reaction:R-XTR-177275] PKA phosphorylates DARPP-32 on Thr34 - Xenopus tropicalis
referenceEntity	[ReferenceGeneProduct:uniprot:A4II07] UniProt:A4II07
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-177274
startCoordinate	1

(input)	[Reaction:R-XTR-180038] DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function
(activeUnit)	[CatalystActivity:10662736] protein phosphatase regulator activity of Phosphorylated (T34) DARPP-32:PP1A [cytosol]
(output)	[Reaction:R-XTR-177275] PKA phosphorylates DARPP-32 on Thr34
(hasComponent)	[Complex:R-XTR-180025] Phosphorylated (T34) DARPP-32:PP1A [cytosol]
(inferredTo)	[DefinedSet:R-HSA-180075] DARPP-32 phosphorylated on T34 [cytosol] [EntityWithAccessionedSequence:R-HSA-177274] p-T34-PPP1R1B [cytosol]

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