Reactome | NEU2 cleaves GM3 to form LacCer (cytosol)

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NEU2 cleaves GM3 to form LacCer (cytosol) Show undefined attributes

catalystActivity	[CatalystActivity:10684120] exo-alpha-sialidase activity of NEU2 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10684122
displayName	NEU2 cleaves GM3 to form LacCer (cytosol)
eventOf	[Pathway:R-XTR-9840310] Glycosphingolipid catabolism - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-1605723] NEU2 cleaves GM3 to form LacCer (cytosol) - Homo sapiens
input	[SimpleEntity:R-ALL-1605590] GM3 [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	NEU2 cleaves GM3 to form LacCer (cytosol)
output	[SimpleEntity:R-ALL-1605647] LacCer [cytosol] [SimpleEntity:R-ALL-428633] Neu5Ac [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-1605723
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-9840310] Glycosphingolipid catabolism
(inferredTo)	[Reaction:R-HSA-1605723] NEU2 cleaves GM3 to form LacCer (cytosol)

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