Reactome | NEU2 cleaves GM3 to form LacCer (cytosol)

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NEU2 cleaves GM3 to form LacCer (cytosol) Show undefined attributes

authored	[InstanceEdit:1605804] Jassal, Bijay, 2011-09-21
catalystActivity	[CatalystActivity:1605672] exo-alpha-sialidase activity of NEU2 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1605804] Jassal, Bijay, 2011-09-21
dbId	1605723
displayName	NEU2 cleaves GM3 to form LacCer (cytosol)
edited	[InstanceEdit:1605804] Jassal, Bijay, 2011-09-21
eventOf	[Pathway:R-HSA-9840310] Glycosphingolipid catabolism - Homo sapiens
input	[SimpleEntity:R-ALL-1605590] GM3 [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1605663] Cloning and characterization of NEU2, a human gene homologous to rodent soluble sialidases
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	NEU2 cleaves GM3 to form LacCer (cytosol)
orthologousEvent	[Reaction:R-GGA-1605723] NEU2 cleaves GM3 to form LacCer (cytosol) - Gallus gallus [Reaction:R-XTR-1605723] NEU2 cleaves GM3 to form LacCer (cytosol) - Xenopus tropicalis [Reaction:R-DRE-1605723] NEU2 cleaves GM3 to form LacCer (cytosol) - Danio rerio [Reaction:R-SSC-1605723] NEU2 cleaves GM3 to form LacCer (cytosol) - Sus scrofa [Reaction:R-BTA-1605723] NEU2 cleaves GM3 to form LacCer (cytosol) - Bos taurus [Reaction:R-CFA-1605723] NEU2 cleaves GM3 to form LacCer (cytosol) - Canis familiaris [Reaction:R-RNO-1605723] NEU2 cleaves GM3 to form LacCer (cytosol) - Rattus norvegicus [Reaction:R-MMU-1605723] NEU2 cleaves GM3 to form LacCer (cytosol) - Mus musculus
output	[SimpleEntity:R-ALL-1605647] LacCer [cytosol] [SimpleEntity:R-ALL-428633] Neu5Ac [cytosol]
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1863068] Stephan, Ralf, 2011-10-31
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1605723
summation	[Summation:1605783] Sialidase-2 (NEU2) hydrolyses Neu5Ac from GM3 in the cytosol...
updateTrackers	[UpdateTracker:9787049] Update Tracker - [Reaction:1605723] Neu5Ac is cleaved from GM3 by NEU2 to form a globoside (cytosol) - v46:[add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9787049] Update Tracker - [Reaction:1605723] Neu5Ac is cleaved from GM3 by NEU2 to form a globoside (cytosol) - v46:[add_removeOutput]
(hasEvent)	[Pathway:R-HSA-9840310] Glycosphingolipid catabolism

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