Reactome | Glycosphingolipid catabolism

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Glycosphingolipid catabolism Show undefined attributes

compartment	[Compartment:161320] lysosomal lumen [Compartment:17938] lysosomal membrane [Compartment:3828046] multivesicular body lumen [Compartment:3828050] multivesicular body, internal vesicle [Compartment:3828048] multivesicular body, internal vesicle membrane [Compartment:876] plasma membrane
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10730386
displayName	Glycosphingolipid catabolism
eventOf	[Pathway:R-XTR-1660662] Glycosphingolipid metabolism - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:20513] glycosphingolipid catabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-XTR-1605717] GM2A binds and mobilizes ligands - Xenopus tropicalis [Reaction:R-XTR-1605624] Beta-galactosidases hydrolyse mobilized GM1 to mobilized GM2 - Xenopus tropicalis [Reaction:R-XTR-9840795] Beta-galactosidases hydrolyze GM2A:GA1 to GM2A:GA2 - Xenopus tropicalis [Reaction:R-XTR-9840833] bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer - Xenopus tropicalis [Reaction:R-XTR-9840949] ARSA removes sulfate from SM3 - Xenopus tropicalis [Reaction:R-XTR-1614362] SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases - Xenopus tropicalis [Reaction:R-XTR-1614336] SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases - Xenopus tropicalis [Reaction:R-XTR-2248891] M6PR transports activated ARSA to the lysosome - Xenopus tropicalis [Reaction:R-XTR-1605797] SMPD1 hydrolyzes SPHM - Xenopus tropicalis [Reaction:R-XTR-1606273] SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) - Xenopus tropicalis [Reaction:R-XTR-1640164] ENPP7 hydrolyzes sphingomyelin - Xenopus tropicalis [Reaction:R-XTR-1605723] NEU2 cleaves GM3 to form LacCer (cytosol) - Xenopus tropicalis [Reaction:R-XTR-1605768] NEU3 cleaves GM3 to form LacCer (plasma membrane) - Xenopus tropicalis [Reaction:R-XTR-1606583] ASAH2 hydrolyzes ceramide (plasma membrane) - Xenopus tropicalis
inferredFrom	[Pathway:R-HSA-9840310] Glycosphingolipid catabolism - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Glycosphingolipid catabolism
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-9840310
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-1660662] Glycosphingolipid metabolism
(inferredTo)	[Pathway:R-HSA-9840310] Glycosphingolipid catabolism

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