Reactome | CYLD:SPATA2:LUBAC [cytosol]

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CYLD:SPATA2:LUBAC [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-SSC-9796343] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] - Sus scrofa [Complex:R-SSC-9817389] TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] - Sus scrofa [Complex:R-SSC-9817409] TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] - Sus scrofa [Complex:R-SSC-9818791] TNF?:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] - Sus scrofa
consumedByEvent	[Reaction:R-SSC-9796379] CYLD:SPATA2:LUBAC binds TNFR1 signaling complex - Sus scrofa
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10453576
displayName	CYLD:SPATA2:LUBAC [cytosol]
hasComponent	2 × [EntityWithAccessionedSequence:R-SSC-741420] CYLD [cytosol] 2 × [Complex:R-SSC-5357865] LUBAC [cytosol] 2 × [EntityWithAccessionedSequence:R-SSC-9796351] SPATA2 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-9796690] CYLD:SPATA2:LUBAC [cytosol] - Homo sapiens
maxDepth	3
name	CYLD:SPATA2:LUBAC
producedByEvent	[Reaction:R-SSC-9796691] SPATA2 links CYLD to LUBAC - Sus scrofa [BlackBoxEvent:R-SSC-9818975] CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex - Sus scrofa [BlackBoxEvent:R-SSC-9817400] CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex - Sus scrofa
schemaClass	Complex
species	[Species:49633] Sus scrofa
stId	R-SSC-9796690
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(hasComponent)	[Complex:R-SSC-9818791] TNF?:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] [Complex:R-SSC-9817409] TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] [Complex:R-SSC-9796343] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] [Complex:R-SSC-9817363] TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] [Complex:R-SSC-9817389] TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane]
(output)	[BlackBoxEvent:R-SSC-9817400] CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex [BlackBoxEvent:R-SSC-9818975] CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex [Reaction:R-SSC-9796691] SPATA2 links CYLD to LUBAC
(input)	[Reaction:R-SSC-9796379] CYLD:SPATA2:LUBAC binds TNFR1 signaling complex
(inferredTo)	[Complex:R-HSA-9796690] CYLD:SPATA2:LUBAC [cytosol]

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