Reactome | NF-kappa-B complex is transported from cytosol to nucleus

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NF-kappa-B complex is transported from cytosol to nucleus Show undefined attributes

category	transition
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10459483
displayName	NF-kappa-B complex is transported from cytosol to nucleus
eventOf	[Pathway:R-SSC-933542] TRAF6 mediated NF-kB activation - Sus scrofa [Pathway:R-SSC-445989] TAK1-dependent IKK and NF-kappa-B activation - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-168166] NF-kappa-B complex is transported from cytosol to nucleus - Homo sapiens
input	[Complex:R-SSC-168155] NFKB1(1-433), NFKB2(1-454):RELA [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	NF-kappa-B complex is transported from cytosol to nucleus
output	[Complex:R-SSC-177673] NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm]
precedingEvent	[Reaction:R-SSC-168140] Active IKK Complex phosphorylates NF-kappa-B inhibitor - Sus scrofa [Reaction:R-SSC-9773803] Active IKBKB phosphorylates NF-kappa-B inhibitor - Sus scrofa
regulatedBy	[PositiveRegulation:10459484] Positive regulation by 'AGER ligands:AGER [plasma membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-168166
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-445989] TAK1-dependent IKK and NF-kappa-B activation [Pathway:R-SSC-933542] TRAF6 mediated NF-kB activation
(inferredTo)	[Reaction:R-HSA-168166] NF-kappa-B complex is transported from cytosol to nucleus

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