Reactome | Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer

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Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer Show undefined attributes

catalystActivity	[CatalystActivity:10546203] ubiquitin-protein transferase activity of ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10546205
displayName	Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer
eventOf	[Pathway:R-SSC-9645460] Alpha-protein kinase 1 signaling pathway - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Polymerisation:R-SSC-9645394] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation - Sus scrofa
inferredFrom	[BlackBoxEvent:R-HSA-9645414] Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer - Homo sapiens
input	[Complex:R-SSC-9645440] ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer [cytosol] 9 × [DefinedSet:R-SSC-113595] Ub [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer
output	[Complex:R-SSC-9645508] ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol]
precedingEvent	[Reaction:R-SSC-9645501] TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex - Sus scrofa
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49633] Sus scrofa
stId	R-SSC-9645414
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-9645460] Alpha-protein kinase 1 signaling pathway
(precedingEvent)	[Polymerisation:R-SSC-9645394] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation
(inferredTo)	[BlackBoxEvent:R-HSA-9645414] Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer

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