Reactome | Phosphorylation of STAT1 by JAK kinases

Schema > Reaction > Entries

Phosphorylation of STAT1 by JAK kinases Show undefined attributes

catalystActivity	[CatalystActivity:10482797] protein tyrosine kinase activity of STAT1 bound to p-IFNGR1 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10482799
displayName	Phosphorylation of STAT1 by JAK kinases
eventOf	[Pathway:R-SSC-877300] Interferon gamma signaling - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-909552] Phosphorylation of STAT1 at Ser727 - Sus scrofa
inferredFrom	[Reaction:R-HSA-873922] Phosphorylation of STAT1 by JAK kinases - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-SSC-873828] STAT1 bound to p-IFNGR1 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylation of STAT1 by JAK kinases
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-SSC-873817] p-STAT1(Y701) bound to p-IFNGR1 [plasma membrane]
precedingEvent	[Reaction:R-SSC-873921] Binding of STAT1 to p-IFNGR1 - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-873922
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-877300] Interferon gamma signaling
(precedingEvent)	[Reaction:R-SSC-909552] Phosphorylation of STAT1 at Ser727
(inferredTo)	[Reaction:R-HSA-873922] Phosphorylation of STAT1 by JAK kinases

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