Reactome | Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3

Schema > BlackBoxEvent > Entries

Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 Show undefined attributes

catalystActivity	[CatalystActivity:10464852] protein serine/threonine kinase activity of p-T,Y MAPK dimers [nucleoplasm]
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10544621
displayName	Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3
eventOf	[Pathway:R-SSC-8939211] ESR-mediated signaling - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-9032751] Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-SSC-8939185] ESR1:chaperone complex [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [DefinedSet:R-SSC-5082416] HSP-90 [nucleoplasm] [Complex:R-SSC-9032748] p-S118-ESR1 dimer [nucleoplasm] [SimpleEntity:R-ALL-113550] Pi [nucleoplasm] [EntityWithAccessionedSequence:R-SSC-5082403] PTGES3 [nucleoplasm] [CandidateSet:R-SSC-8939175] TPR-containing co-chaperones [nucleoplasm]
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49633] Sus scrofa
stId	R-SSC-9032751
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-8939211] ESR-mediated signaling
(inferredTo)	[BlackBoxEvent:R-HSA-9032751] Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3

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