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Schema
>
BlackBoxEvent
>
Entries
Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3
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authored
[InstanceEdit:9038276] Rothfels, Karen, 2018-02-23
catalystActivity
[CatalystActivity:198713] protein serine/threonine kinase activity of p-T,Y MAPK dimers [nucleoplasm]
category
omitted
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:9032750] Rothfels, Karen, 2017-12-18
dbId
9032751
displayName
Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3
edited
[InstanceEdit:9038276] Rothfels, Karen, 2018-02-23
eventOf
[Pathway:R-HSA-8939211] ESR-mediated signaling - Homo sapiens
input
[SimpleEntity:R-ALL-29358] ATP [nucleoplasm]
[Complex:R-HSA-8939185] ESR1:chaperone complex [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9032706] Peptide growth factors elicit estrogen receptor-dependent transcriptional activation of an estrogen-responsive element
[LiteratureReference:9032732] HER-2 tyrosine kinase pathway targets estrogen receptor and promotes hormone-independent growth in human breast cancer cells
[LiteratureReference:9032740] Insulin-like growth factors activate estrogen receptor to control the growth and differentiation of the human neuroblastoma cell line SK-ER3
[LiteratureReference:9032698] The unliganded estrogen receptor (ER) transduces growth factor signals
[LiteratureReference:9032699] Modulation of the ligand-independent activation of the human estrogen receptor by hormone and antihormone
[LiteratureReference:9032689] Stimulation of estrogen receptor-mediated transcription and alteration in the phosphorylation state of the rat uterine estrogen receptor by estrogen, cyclic adenosine monophosphate, and insulin-like growth factor-I
[LiteratureReference:9032726] Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation
[LiteratureReference:9032708] Phosphorylation of human estrogen receptor alpha at serine 118 by two distinct signal transduction pathways revealed by phosphorylation-specific antisera
[LiteratureReference:9032721] A functional serine 118 phosphorylation site in estrogen receptor-alpha is required for down-regulation of gene expression by 17beta-estradiol and 4-hydroxytamoxifen
[LiteratureReference:9024048] Estrogen receptor alpha phosphorylation and its functional impact in human breast cancer
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3
output
[SimpleEntity:R-ALL-113582] ADP [nucleoplasm]
[DefinedSet:R-HSA-5082416] HSP-90 [nucleoplasm]
[Complex:R-HSA-9032748] p-S118-ESR1 dimer [nucleoplasm]
[SimpleEntity:R-ALL-113550] Pi [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-5082403] PTGES3 [nucleoplasm]
[CandidateSet:R-HSA-8939175] TPR-containing co-chaperones [nucleoplasm]
releaseDate
2018-03-21
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9038169] Magnani, Luca, 2018-02-23
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-9032751
summation
[Summation:9032747] ESR1-mediated signaling can be initiated in an estrogen-inde...
Referrals
(hasEvent)
[Pathway:R-HSA-8939211] ESR-mediated signaling
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