Reactome | IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2

Schema > BlackBoxEvent > Entries

IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 Show undefined attributes

catalystActivity	[CatalystActivity:10542801] transmembrane receptor protein tyrosine kinase activity of IFNL1:IFNLR1:JAK1:IL10RB:TYK2 [plasma membrane]
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10542803
displayName	IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2
eventOf	[Pathway:R-SSC-8854691] Interleukin-20 family signaling - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-8987040] IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 - Sus scrofa
inferredFrom	[BlackBoxEvent:R-HSA-8987202] IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-SSC-448637] IFNL1:IFNLR1:JAK1:IL10RB:TYK2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 JAK1 and TYK2 are phosphorylated by IFNL1:IFNLR1:JAK1:IL10RB:TYK2 receptor complex JAK1 and tyk2 are phosphorylated after il29-il29 receptor interaction
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-SSC-8987259] IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 [plasma membrane]
precedingEvent	[Reaction:R-SSC-448661] IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 - Sus scrofa
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49633] Sus scrofa
stId	R-SSC-8987202
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-8854691] Interleukin-20 family signaling
(precedingEvent)	[Reaction:R-SSC-8987040] IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1
(inferredTo)	[BlackBoxEvent:R-HSA-8987202] IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2

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