Reactome | IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1

Schema > Reaction > Entries

IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region [Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10480031
displayName	IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1
eventOf	[Pathway:R-SSC-449836] Other interleukin signaling - Sus scrofa [Pathway:R-SSC-8854691] Interleukin-20 family signaling - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-SSC-8987202] IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 - Sus scrofa
inferredFrom	[Reaction:R-HSA-448661] IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 - Homo sapiens
input	[Complex:R-SSC-8987216] IFNLR1:JAK1 [plasma membrane] [Complex:R-SSC-6784360] IL10RB:TYK2 [plasma membrane] [EntityWithAccessionedSequence:R-SSC-448598] IL29 [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 receptor complex Interleukin 28 receptor binds Interleukin-28/29
output	[Complex:R-SSC-448637] IFNL1:IFNLR1:JAK1:IL10RB:TYK2 [plasma membrane]
precedingEvent	[Reaction:R-SSC-8987120] JAK1 binds IFNLR1 - Sus scrofa [Reaction:R-SSC-8987223] IL10RB binds TYK2 - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-448661
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-8854691] Interleukin-20 family signaling [Pathway:R-SSC-449836] Other interleukin signaling
(precedingEvent)	[BlackBoxEvent:R-SSC-8987202] IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2
(inferredTo)	[Reaction:R-HSA-448661] IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1

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