Reactome | IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2

Schema > BlackBoxEvent > Entries

IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 Show undefined attributes

authored	[InstanceEdit:8982160] Duenas, Corina, 2017-03-16
catalystActivity	[CatalystActivity:9005789] transmembrane receptor protein tyrosine kinase activity of IFNL1:IFNLR1:JAK1:IL10RB:TYK2 [plasma membrane]
category	uncertain
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:8987035] Duenas, Corina, 2017-05-05
dbId	8987202
displayName	IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2
edited	[InstanceEdit:9028437] Jupe, Steve, 2017-11-07
eventOf	[Pathway:R-HSA-8854691] Interleukin-20 family signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-8987040] IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-448637] IFNL1:IFNLR1:JAK1:IL10RB:TYK2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8987062] A role for IFN-lambda1 in multiple myeloma B cell growth [LiteratureReference:8987128] Role of the interleukin (IL)-28 receptor tyrosine residues for antiviral and antiproliferative activity of IL-29/interferon-lambda 1: similarities with type I interferon signaling (Dumoutier et al. ).
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 JAK1 and TYK2 are phosphorylated by IFNL1:IFNLR1:JAK1:IL10RB:TYK2 receptor complex JAK1 and tyk2 are phosphorylated after il29-il29 receptor interaction
orthologousEvent	[BlackBoxEvent:R-GGA-8987202] IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 - Gallus gallus [BlackBoxEvent:R-XTR-8987202] IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 - Xenopus tropicalis [BlackBoxEvent:R-DRE-8987202] IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 - Danio rerio [BlackBoxEvent:R-SSC-8987202] IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 - Sus scrofa [BlackBoxEvent:R-BTA-8987202] IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 - Bos taurus [BlackBoxEvent:R-CFA-8987202] IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 - Canis familiaris [BlackBoxEvent:R-RNO-8987202] IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 - Rattus norvegicus [BlackBoxEvent:R-MMU-8987202] IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-8987259] IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-448661] IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 - Homo sapiens
releaseDate	2017-12-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9029252] Datta, Sandip K, 2017-11-15
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-8987202
summation	[Summation:9005406] Tyrosine-protein kinase JAK1 (JAK1) and Non-receptor tyrosin...

Referrals

(hasEvent)	[Pathway:R-HSA-8854691] Interleukin-20 family signaling
(precedingEvent)	[Reaction:R-HSA-8987040] IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1

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